Interleukin 1 Alpha mRNA-Expressing Cells on the Local Inflammatory Response in Feline Infectious Peritonitis

Journal of Veterinary Medical Science

Atsuhiko HASEGAWA¹  Takashi HASEGAWA¹ 

关键词: distribution;    FIP;    IL-1α;    in situ hybridization;    mRNA;   

DOI  :  10.1292/jvms.53.995

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(42)Cited-By(6)By in situ hybridization with biotinylated human interleukin 1α(IL-1α) cDNA probe, distribution of feline IL-1α mRNA-expressing cells was examined in the tissues from 49 cases diagnosed as feline infectious peritonitis (FIP) by pathological examination. IL-1α mRNA-expressing cells were found in visceral peritoneum, lymphoid organs, liver, kidney, pancreas, digestive tract, lung, pleura, brain, palpebral conjunctiva, and bone marrow. Hybridization signals for IL-1α mRNA were mostly located in the local inflammatory lesions on the serosal surface of various organs and omentum, which were frequently involved in the lesions of FIP (27.8±5.1 cells/mm2). Morphological examination suggested that they were infiltrated macrophages. However, few IL-1α mRNA-expressing macrophages were in the lesions of other organs. These data suggested that IL-1α produced from macrophages in the local inflammatory sites might participate in the initiation and development of the lesions on the visceral peritoneum in FIP.

【 授权许可】

Unknown