Computed tomography shows high fracture prevalence among physically active forager-horticulturalists with high fertility

eLife

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[1] Center for Evolution and Medicine, Arizona State University, Tempe, United States;School of Human Evolution and Social Change, Arizona State University, Tempe, United States;Department of Anthropology, University of California, Santa Barbara, Santa Barbara, United States;Economic Science Institute, Chapman University, Orange, United States;Leonard Davis School of Gerontology, University of Southern California, Los Angeles, United States;Los Angeles Biomedical Research Institute, Harbor-University of California at Los Angeles Medical Center, Torrance, United States;School of Medicine, Emory University, Atlanta, United States;Université Toulouse 1 Capitole, Toulouse, France;Institute for Advanced Study in Toulouse, Toulouse, France;

关键词: skeletal gracility;    life history theory;    human evolution;    osteoporosis;    bone mineral density;    Human;   

DOI  :  10.7554/eLife.48607

来源: publisher

【 摘 要 】

10.7554/eLife.48607.001Modern humans have more fragile skeletons than other hominins, which may result from physical inactivity. Here, we test whether reproductive effort also compromises bone strength, by measuring using computed tomography thoracic vertebral bone mineral density (BMD) and fracture prevalence among physically active Tsimane forager-horticulturalists. Earlier onset of reproduction and shorter interbirth intervals are associated with reduced BMD for women. Tsimane BMD is lower versus Americans, but only for women, contrary to simple predictions relying on inactivity to explain skeletal fragility. Minimal BMD differences exist between Tsimane and American men, suggesting that systemic factors other than fertility (e.g. diet) do not easily explain Tsimane women’s lower BMD. Tsimane fracture prevalence is also higher versus Americans. Lower BMD increases Tsimane fracture risk, but only for women, suggesting a role of weak bone in women’s fracture etiology. Our results highlight the role of sex-specific mechanisms underlying skeletal fragility that operate long before menopause.

【 授权许可】

CC BY