Distinct roles of striatal direct and indirect pathways in value-based decision making

eLife

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[1] Center for Synaptic Brain Dysfunctions, Institute for Basic Science, Daejeon, Republic of Korea;Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea;

关键词: basal ganglia;    D1 receptor;    D2 receptor;    reversal;    dynamic foraging;    reinforcement learning;    Mouse;   

DOI  :  10.7554/eLife.46050

来源: publisher

【 摘 要 】

10.7554/eLife.46050.001The striatum is critically involved in value-based decision making. However, it is unclear how striatal direct and indirect pathways work together to make optimal choices in a dynamic and uncertain environment. Here, we examined the effects of selectively inactivating D1 receptor (D1R)- or D2 receptor (D2R)-expressing dorsal striatal neurons (corresponding to direct- and indirect-pathway neurons, respectively) on mouse choice behavior in a reversal task with progressively increasing reversal frequency and a dynamic two-armed bandit task. Inactivation of either D1R- or D2R-expressing striatal neurons impaired performance in both tasks, but the pattern of altered choice behavior differed between the two animal groups. A reinforcement learning model-based analysis indicated that inactivation of D1R- and D2R-expressing striatal neurons selectively impairs value-dependent action selection and value learning, respectively. Our results suggest differential contributions of striatal direct and indirect pathways to two distinct steps in value-based decision making.

【 授权许可】

CC BY