Neuropeptide B mediates female sexual receptivity in medaka fish, acting in a female-specific but reversible manner

eLife

  ^{1    1    1    1    1    1    1    1    2    3    4    5    6    7} 

[1] Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan;Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Department of Pathophysiology, Tokyo Medical University, Tokyo, Japan;Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan;Laboratory for Systems Molecular Ethology, RIKEN Center for Brain Science, Wako, Japan;Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan;Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University, Kyoto, Japan;Laboratory of Bioresources, National Institute for Basic Biology, Okazaki, Japan;Division of Reproductive Biology, National Institute for Basic Biology, Okazaki, Japan;

关键词: neuropeptide B;    sexual dimorphism;    sexual lability;    sex steroid;    mating behavior;    female receptivity;    Other;   

DOI  :  10.7554/eLife.39495

来源: publisher

【 摘 要 】

10.7554/eLife.39495.001Male and female animals display innate sex-specific mating behaviors. In teleost fish, altering the adult sex steroid milieu can effectively reverse sex-typical mating behaviors, suggesting remarkable sexual lability of their brains as adults. In the teleost medaka, neuropeptide B (NPB) is expressed female-specifically in the brain nuclei implicated in mating behavior. Here, we demonstrate that NPB is a direct mediator of estrogen action on female mating behavior, acting in a female-specific but reversible manner. Analysis of regulatory mechanisms revealed that the female-specific expression of NPB is dependent on direct transcriptional activation by estrogen via an estrogen-responsive element and is reversed in response to changes in the adult sex steroid milieu. Behavioral studies of NPB knockouts revealed that female-specific NBP mediates female receptivity to male courtship. The female-specific NPB signaling identified herein is presumably a critical element of the neural circuitry underlying sexual dimorphism and lability of mating behaviors in teleosts.

【 授权许可】

CC BY