Skin vasculature and hair follicle cross-talking associated with stem cell activation and tissue homeostasis

eLife

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[1] Molecular Biology and Genetics, Cornell University, Ithaca, United States;

关键词: hair follicle stem cells;    vascular niche;    Alk1;    Runx1;    skin vasculature;    hair cycle;    Mouse;   

DOI  :  10.7554/eLife.45977

来源: publisher

【 摘 要 】

10.7554/eLife.45977.001Skin vasculature cross-talking with hair follicle stem cells (HFSCs) is poorly understood. Skin vasculature undergoes dramatic remodeling during adult mouse hair cycle. Specifically, a horizontal plexus under the secondary hair germ (HPuHG) transiently neighbors the HFSC activation zone during the quiescence phase (telogen). Increased density of HPuHG can be induced by reciprocal mutations in the epithelium (Runx1) and endothelium (Alk1) in adult mice, and is accompanied by prolonged HFSC quiescence and by delayed entry and progression into the hair growth phase (anagen). Suggestively, skin vasculature produces BMP4, a well-established HFSC quiescence-inducing factor, thus contributing to a proliferation-inhibitory environment near the HFSC. Conversely, the HFSC activator Runx1 regulates secreted proteins with previously demonstrated roles in vasculature remodeling. We suggest a working model in which coordinated remodeling and molecular cross-talking of the adult epithelial and endothelial skin compartments modulate timing of HFSC activation from quiescence for proper tissue homeostasis of adult skin.

【 授权许可】

CC BY