An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway

eLife

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[1] Department of Neuroscience, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands;Institut des Neurosciences de la Timone, Centre National de la Recherche Scientifique (CNRS), Aix-Marseille Université, Marseille, France;Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, United States;Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, United States;Neurobiology Research Unit, Okinawa Institute of Science and Technology, Okinawa, Japan;Department of Neuroscience, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands;Japan Society for the Promotion of Sciences, Tokyo, Japan;Neurobiology Research Unit, Okinawa Institute of Science and Technology, Okinawa, Japan;Neurobiology Research Unit, Okinawa Institute of Science and Technology, Okinawa, Japan;Japan Society for the Promotion of Sciences, Tokyo, Japan;

关键词: basal ganglia;    motor cortex;    rabies tracing;    electrophysiology;    Mouse;   

DOI  :  10.7554/eLife.49995

来源: publisher

【 摘 要 】

10.7554/eLife.49995.001Cortico-basal ganglia-thalamocortical loops are largely conceived as parallel circuits that process limbic, associative, and sensorimotor information separately. Whether and how these functionally distinct loops interact remains unclear. Combining genetic and viral approaches, we systemically mapped the limbic and motor cortico-basal ganglia-thalamocortical loops in rodents. Despite largely closed loops within each functional domain, we discovered a unidirectional influence of the limbic over the motor loop via ventral striatum-substantia nigra (SNr)-motor thalamus circuitry. Slice electrophysiology verifies that the projection from ventral striatum functionally inhibits nigro-thalamic SNr neurons. In vivo optogenetic stimulation of ventral or dorsolateral striatum to SNr pathway modulates activity in medial prefrontal cortex (mPFC) and motor cortex (M1), respectively. However, whereas the dorsolateral striatum-SNr pathway exerts little impact on mPFC, activation of the ventral striatum-SNr pathway effectively alters M1 activity. These results demonstrate an open cortico-basal ganglia loop whereby limbic information could modulate motor output through ventral striatum control of M1.

【 授权许可】

CC BY