Modulation of tonotopic ventral medial geniculate body is behaviorally relevant for speech recognition

eLife

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[1] Chair of Cognitive and Clinical Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany;Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands;Maastricht Brain Imaging Center (MBIC), Maastricht, Netherlands;Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, United States;Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, Netherlands;Maastricht Brain Imaging Center (MBIC), Maastricht, Netherlands;Maastricht Centre for Systems Biology (MaCSBio), Maastricht University, Maastricht, Netherlands;Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany;Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany;Chair of Cognitive and Clinical Neuroscience, Faculty of Psychology, Technische Universität Dresden, Dresden, Germany;

关键词: ventral MGB;    thalamus;    speech;    top-down modulation;    7T fMRI;    auditory;    Human;   

DOI  :  10.7554/eLife.44837

来源: publisher

【 摘 要 】

10.7554/eLife.44837.001Sensory thalami are central sensory pathway stations for information processing. Their role for human cognition and perception, however, remains unclear. Recent evidence suggests an involvement of the sensory thalami in speech recognition. In particular, the auditory thalamus (medial geniculate body, MGB) response is modulated by speech recognition tasks and the amount of this task-dependent modulation is associated with speech recognition abilities. Here, we tested the specific hypothesis that this behaviorally relevant modulation is present in the MGB subsection that corresponds to the primary auditory pathway (i.e., the ventral MGB [vMGB]). We used ultra-high field 7T fMRI to identify the vMGB, and found a significant positive correlation between the amount of task-dependent modulation and the speech recognition performance across participants within left vMGB, but not within the other MGB subsections. These results imply that modulation of thalamic driving input to the auditory cortex facilitates speech recognition.

【 授权许可】

CC BY