Knockdown of lncRNA MNX1‐AS1 suppresses cell proliferation, migration, and invasion in prostate cancer

FEBS Open Bio

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[1] Department of Urology, Jinan Central Hospital Affiliated to Shandong University, China;

关键词: CCAT;    cell proliferation;    EMT;    RNA;    MNX;    prostate cancer;   

DOI  :  10.1002/2211-5463.12611

来源: publisher

【 摘 要 】

Altered expression of long non‐coding RNAs (lncRNAs) has been reported in many malignancies, including prostate cancer. However, the role of lncRNA MNX1‐AS1 in prostate cancer has not been reported. Here, we report that MNX1‐AS1 is expressed in prostate cancer tissues and cells and that siRNA‐mediated knockdown of MNX1‐AS1 inhibits proliferation, migration, and invasion of prostate cancer DU145 and PC3 cells. In addition, down‐regulation of MNX1‐AS1 decreased expression of proliferating cell nuclear antigen, PH‐3, N‐cadherin, and vimentin, but enhanced expression of E‐cadherin. In conclusion, this is the first report that knockdown of MNX1‐AS1 suppresses prostate cancer cell proliferation, migration, and invasion. We believe that MNX1‐AS1 may be a potential new therapeutic target for prostate cancer patients.

【 授权许可】

Unknown