Delta-Aminolevulinic Acid Dehydratase Inhibition and RBC Abnormalities in Relation to Blood Lead among Selected Jordanian Workers.

Jordan Journal of Biological Sciences

Ziad A. Shraideh¹ 

关键词: Blood lead;    Lead toxicity;    δ-ALAD;    RBC morphology;    SEM.;   

DOI  :  

学科分类：生物科学（综合）

来源: Hashemite University, Deanship of Research and Higher Studies

【 摘 要 】

Lead toxicity is a public health hazard particularly to the occupationally exposed workers. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study is conducted to assess lead cytotoxicity and the antioxidant status of selected groups of Jordanian workers occupationally exposed to lead poisoning or automobile buffs. A total of ninety male workers were selected for the study. The workers studied included: Radiator welders, exhaust workers, automobile electronics and mechanics, metal workers, and car painters in Amman city. The control group included 20 subjects of the same age group without any occupational exposure to lead. A number of biological parameters have been studied in order to estimate the degree of lead intoxication in the selected worker groups. The groups did not significantly differ among each other in the average of age (34± 0.9) and work years (17.1±1.8). The researchers studied the effect of exposure to lead on the activity of δ-ALAD (a key enzyme in heme biosynthesis). A significant decrease and a negative correlation between δ-ALAD and blood lead were observed in all the studied worker groups. The effect of exposure to lead on the morphology of RBCs was investigated. Fibrillation and particulate structures on the surface of RBCs and irregularplasma membrane evaginations were seen under scanning electron microscope.Determination of blood-lead concentration, δ-ALAD activity as well as morphological investigations of RBCs could be bebenificial in the evaluation of lead toxicity.

【 授权许可】

CC BY