Synthesis, characterization and DPPH scavenging activity of some benzimidazole derivatives

Bulletin of The Chemical Society of Ethiopia

F. Odame¹ 

关键词: Benzimidazole;    o-Phenylenediamine;    Aldehydes;    Base catalysis;    DPPH scavenging activity;   

DOI  :  10.4314/bcse.v32i2.8

学科分类：化学（综合）

来源: Chemical Society of Ethiopia

【 摘 要 】

A base-catalyzed conversion of aldehydes to benzimidazoles has been achieved. The compounds have been characterized by IR, NMR, micoranalysis, and GC-MS. The reaction for the formation of benzimidazoles has been monitored with ¹H NMR and IR. The crystal structures of two derivatives, 2-(2-chlorophenyl)-1 H -benzimidazole and 2-(1 H -benzimidazol-2-yl)-4-nitrophenol, are presented. A study of the DPPH scavenging activity of these compounds showed that 2-(1 H -benzimidazol-2-yl)phenol ( 2 ), 2- p -tolyl-1 H -benzimidazole ( 3 ) and 2-(4-methoxyphenyl)-1 H -benzimidazole ( 7 ) gave IC₅₀ values 1974, 773 and 800 µM.

【 授权许可】

Unknown