Interaction of Glutathione S-Transferase M1, T1, and P1 Genes With Early Life Tobacco Smoke Exposure on Lung Function in Adolescents

Chest: The Journal of Circulation, Respiration and Related Systems

Shyamali C. Dharmage^1,2¹  Caroline J. Lodge^1^1,12  Jennifer L. Perret^1^1,14  Nilakshi T. Waidyatillake^1^2,23  Jennie Hui^4,5,6^3,34  Bircan Erbas^7^3,35  Xin Dai^1^3,36  Michael J. Abramson^8^4,47  Adrian J. Lowe^1,2^4,48  Cecilie Svanes^9^5,51  Gayan Bowatte^1,3^5,52  John A. Burgess^1^5,56 

[1] Affiliate Assistant Professor, University of South Florida, Tampa, FL Adjunct Professor, Barry University School of Law, Orlando, FL. Dr. Friedman is Associate Professor of Psychological Medicine, University of Auckland Staff Psychiatrist, Mason Clinic, Auckland Regional Forensic Psychiatry Services, Auckland, New Zealand the Philip Resnick Professor of Forensic Psychiatry, Case Western Reserve University, Cleveland, OH. Dr. Jain is a Forensic Psychiatry Research Fellow, Columbia University and New York State Psychiatric Institute, New York, NY. Dr. Wagoner is Assistant Professor, University of South Florida College of Medicine, Tampa, FL. Portions of this article were presented at the 2017 American Psychiatric Association Annual Meeting, May 20–24, 2017, in San Diego, CA.^2;Bayer (South East Asia) Pte Ltd, Singapore^49;CNRS, UMR_7210, Paris F-75012, France^30;Centre for International Health, University of Bergen, Bergen, Norway^58;Department of Medicine, Kuala Lumpur, Malaysia^43;Department of Neurology, Jakarta, Indonesia^41;Department of Surgery (Ophthalmology), The University of Melbourne, Victoria, Australia^33;Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China^24;Neurology Department, Ho Chi Minh City, Vietnam^47;Novena Heart Centre, Singapore^45;Ophthalmology, Department of Surgery, University of Melbourne, Melbourne, Australia^16;Ophthalmology, Department of Surgery, University of Melbourne^12;Philippine Heart Center, Quezon City, Philippines^38;Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia^5;Royal Victorian Eye and Ear Hospital, Melbourne, Australia^13;UPMC Univ Paris 06, UMR_S 968, Institut de la Vision, Paris F-75012, France^29;Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia^51;Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China^26;Brien Holden Vision Institute and School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia^18;Busselton Population Medical Research Institute, WA, Australia^56;Cardiology Clinical Academic Group St. George's, University of London and Imperial College, London, United Kingdom^50;Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital^32;Centre for Eye Research Australia^4;Centre for Food and Allergy Research, Murdoch Children’s Research Institute, Parkville, VIC, Australia^52;Chang Gung Memorial Hospital, Taoyuan, Taiwan^36;Chang Gung University^37;Children's University Hospital, Technological University Dublin, Dublin, Ireland^15;Cipto Mangunkusumo National Hospital, Faculty of Medicine Universitas Indonesia^42;Department of Anatomy and Neuroscience, The University of Melbourne, Melbourne, Victoria, Australia^31;Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway^60;Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University Heidelberg, Mannheim, Germany^17;Department of Ophthalmology, Xiang'an Hospital of Xiamen University^23;Department of Psychology, Guangdong Provincial Key Laboratory of Social Cognitive Neuroscience and Mental Health, Guangdong Provincial Key Laboratory of Brain Function and Disease, Sun Yat-sen University, Guangzhou, China^14;Department of Surgery (Ophthalmology), The University of Melbourne, Parkville, Victoria, Australia^6;Division of Optometry and Visual Sciences, School of Health Sciences, City, University of London, United Kingdom^7;Dr. Cooke is Associate Professor, University of Florida College of Medicine, Gainesville, FL. Dr. Hall is Assistant Professor of Psychiatry, University of Central Florida College of Medicine^1;Faculty of Medicine, Thammasat University^40;INSERM, U968, Paris, F-75012, France^28;Institute of Child Health, University College London and Great Ormond Street Hospital for Children, London, United Kingdom^20;Korea University Medical Centre, Seoul, South Korea^34;Mount Elizabeth Novena Specialist Centre^46;National Eye Institute, National Institutes of Health, Bethesda, Maryland, United States^21;National Institute of Fundamental Studies, Kandy, Sri Lanka^53;National Taiwan University Hospital, Taipei, Taiwan^35;National University of Malaysia Medical Centre^44;PathWest Laboratory Medicine of West Australia, Perth, WA, Australia^54;Pediatric Ophthalmology and Adult Strabismus Department, Singapore National Eye Centre (SNEC), Singapore^8;Pediatric Ophthalmology and Strabismus Department, KK Women's and Children's Hospital (KKH), Singapore^9;Pham Ngoc Thach Medical University^48;Quinze-Vingts National Ophthalmology Hospital, Paris and Versailles Saint-Quentin-en-Yvelines University, Versailles, France^27;School of Art and Design, Guangdong University of Technology, Guangzhou, China^11;School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia^3;School of Population and Global Health and School of Pathology and Laboratory Medicine, The University of Western Australia, WA, Australia^55;School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia^57;School of Public Health & Preventive Medicine, Monash University, Melbourne, VIC, Australia^59;State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China^10;Stroke Excellence Center, Pathum Thani, Thailand^39;The Vitreous, Retina, Macula Consultants of New York and the LuEsther T. Mertz Retina Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York, United States^22;Tokyo Medical and Dental University, Tokyo, Japan^19;Xiamen University Affiliated Xiamen Eye Center, Xiamen, Fujian, China^25

关键词: epidemiology (pulmonary);    gene polymorphism;    lung function;    pediatric asthma;    tobacco smoke exposure;    BD;    bronchodilator;    GLI;    Global Lung Function Initiative;    GST;    glutathione S-transferase;    MACS;    Melbourne Atopy Cohort Study;   

DOI  :  10.1016/j.chest.2018.08.1079

学科分类：呼吸医学

来源: American College of Chest Physicians

【 摘 要 】

Background Glutathione S-transferase (GST) genes are involved in the management of oxidative stress in the lungs. We aimed to determine whether they modify the associations between early life smoke exposure and adverse lung health outcomes. Methods The Melbourne Atopy Cohort study (a high-risk birth cohort) enrolled 620 children and followed them prospectively from birth. We recorded perinatal tobacco smoke exposure, asthma, and lung function at 12 (59%) and 18 years (66%) and genotyped for GSTM1, GSTT1, and GSTP1 (69%). Results GST genotypes were found to interact with tobacco smoke exposure on lung function outcomes (P interaction ≤ .05). Only among children with GSTT1 null genotypes was exposure to mother's, father's, or parental tobacco smoke in early life associated with an increased risk of reductions in prebronchodilator (BD) FEV₁ and FVC at both 12 and 18 years. These associations were not seen in children with GSTT1 present. Similarly, only among children with GSTM1 null genotypes was exposure to father's or parental smoking associated with reductions in pre- and post-BD FEV₁ and FVC at 18 years. Only among children with Ile/Ile genotypes of GSTP1 was exposure to mother's smoking associated with increased risk of reduced FEV₁ at 18 years, but this was not the case among children with Val/Val or Ile/Val genotypes. Conclusions Our study provides evidence of interaction between early tobacco smoke exposure and GST genotypes on lung function. Carriers of GST null mutations and GSTP1 Ile/Ile alleles may be more susceptible when exposed to tobacco smoke in early life. These findings support stronger recommendations to protect all infants from tobacco smoke exposure. Trial Registry Australian and New Zealand Clinical Trials Registry; No.: ACTRN12609000734268; URL: http://www.anzctr.org.au/

【 授权许可】

CC BY