Tai Chi and Pulmonary Rehabilitation Compared for Treatment-Naive Patients With COPD: A Randomized Controlled Trial

Chest: The Journal of Circulation, Respiration and Related Systems

Michael I. Polkey^1¹  Zhi-Hui Qiu^2²  Lian Zhou^2³ 

[1] NIHR Respiratory Biomedical Research Unit at the Royal Brompton & Harefield NHS Foundation Trust and Imperial College, London, UK^1;State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, China^2;Xing-Ning People’s Hospital, Meizhou, Guangdong, China^3

关键词: COPD;    indacaterol;    pulmonary rehabilitation;    Tai Chi;    6MWD;    6-min walk distance;    MCID;    minimal clinically important difference;    mMRC;    modified Medical Research Council dyspnea score;    PR;    pulmonary rehabilitation;    SGRQ;    St. George’s Respiratory Questionnaire;   

DOI  :  10.1016/j.chest.2018.01.053

学科分类：呼吸医学

来源: American College of Chest Physicians

【 摘 要 】

Background In COPD, functional status is improved by pulmonary rehabilitation (PR) but requires specific facilities. Tai Chi, which combines psychological treatment and physical exercise and requires no special equipment, is widely practiced in China and is becoming increasingly popular in the rest of the world. We hypothesized that Tai Chi is equivalent (ie, difference less than ±4 St. George's Respiratory Questionnaire [SGRQ] points) to PR. Methods A total of 120 patients (mean FEV₁, 1.11 ± 0.42 L; 43.6% predicted) bronchodilator-naive patients were studied. Two weeks after starting indacaterol 150 μg once daily, they randomly received either standard PR thrice weekly or group Tai Chi five times weekly, for 12 weeks. The primary end point was change in SGRQ prior to and following the exercise intervention; measurements were also made 12 weeks after the end of the intervention. Results The between-group difference for SGRQ at the end of the exercise interventions was –0.48 (95% CI PR vs Tai Chi, –3.6 to 2.6; P = .76), excluding a difference exceeding the minimal clinically important difference. Twelve weeks later, the between-group difference for SGRQ was 4.5 (95% CI, 1.9 to 7.0; P 1 was observed. Conclusions Tai Chi is equivalent to PR for improving SGRQ in COPD. Twelve weeks after exercise cessation, a clinically significant difference in SGRQ emerged favoring Tai Chi. Tai Chi is an appropriate substitute for PR. Trial Registry ClinicalTrials.gov; No.: NCT02665130; URL: www.clinicaltrials.gov.

【 授权许可】

CC BY