Early immunotherapy in cryptogenic new onset refractory status epilepticus (NORSE), a case series

Neurology Asia

Do-Hyung Kim¹ 

关键词: New onset refractory status epilepticus (NORSE);    status epilepticus;    epilepsy;    immunotherapy;   

DOI  :  

学科分类：精神健康和精神病学

来源: Association of South East Asian Nations

【 摘 要 】

To date, there are no clear guidelines for treatment of cryptogenic new onset refractory status epilepticus (NORSE) syndrome. Immunotherapy was effective for some patients, but the initiation time was often somewhat late. We experienced two cryptogenic NORSE syndrome patients with favorable outcomes with early immunotherapy. A 59 years old male patient and a 58 years old female patient visited our hospital in status epilepticus, who were later diagnosed as cryptogenic NORSE after full evaluation. Since seizures were not controlled by two or more antiepileptic drugs in both patients, immunotherapy began on the fifth day of hospitalization. There was improvement on EEG and clinical symptoms, one or two days after initiation of immunotherapy. Early diagnosis of NORSE and early immunotherapy may result in favorable outcome.

【 授权许可】

CC BY