The clinical significance of aortic calcification in chest radiography in community-dwelling, healthy adults: The PRESENT project

Neurology Asia

Kyeong Ho Yun^3¹  Hyungjong Park^1²  Seung Han Suk^4³  Hyun Young Park^2⁴ 

[1] Department of Cardiovascular Medicine, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, Iksan^3;Department of Neurology, Keimyung University College of Medicine, Daegu^1;Department of Neurology, Sanbon Medical Center, Wonkwang University, Ansan Municipal Geriatric Hospital and Center for Prevention of Stroke and Dementia, Gunpo, Korea^4;Department of Neurology^2

关键词: Aortic calcification;    chest radiography;    dementia;    white matter changes;   

DOI  :  

学科分类：精神健康和精神病学

来源: Association of South East Asian Nations

【 摘 要 】

Background: Aortic calcification (AC), a predictor of generalized atherosclerosis, may precedes cerebral white matter lesions. Cerebral white matter changes (WMCs) are associated with cognitive decline and future dementia. The aim of study was to evaluate the usefulness of aortic calcification (AC) detection by chest radiograph for cueing early intervention in possible WMCs to prevent stroke and dementia in community-dwelling healthy people. Methods: We assessed the relationship between AC in chest radiography and vascular risk factors and severity of WMCs in 543 middle-aged and elderly individuals with no history of stroke or dementia. Results: The mean age of the subjects was 61.6 ± 7.4 years. Of these, AC was observed in 39 (7.2%) subjects. AC combined with grade 1 WMC (mild), 2 (moderate), and 3 (severe) were seen in 8 (25.8%), 7 (23.3%) subjects, and 3 (30.0%) subjects, respectively. After adjustment for age and vascular risk factors, diabetes (odds ratio [OR], 1.92, 95% confidence interval (CI) 1.01–3.65, p<0.05) and hypertension (OR, 1.86, 95% CI, 1.03-3.35, p<0.05), aortic knob width (OR, 1.07, 95% CI, 1.01–1.13, p<0.05) and aortic calcification (OR, 2.93, 95% CI, 1.36-6.33, p<0.05) were significantly associated with the severity of WMCs. Conclusion: There is an association between the presence of AC in chest radiography and WMC. It may be useful in providing important information about development of WMCs for prevention of future vascular-related cognitive impairments or ischemic stroke.

【 授权许可】

CC BY