The uses of ethyl 2-(1H-benzo[D]imidazol-2-yl)acetate to synthesis pyrazole, thiophene, pyridine and coumarin derivatives with antitumor activities

Bulletin of The Chemical Society of Ethiopia

R. M. Mohareb¹ 

关键词: Oxobutanamide;    Thiophene;    Pyrazole;    Pyran;    Pyridine;   

DOI  :  10.4314/bcse.v32i3.13

学科分类：化学（综合）

来源: Chemical Society of Ethiopia

【 摘 要 】

In the present work, the ethyl 2-(1 H -benzo[ d ]imidazol-2-yl)acetate ( 3 ) was subjected to a series of heterocyclization reactions through its reaction with different chemical reagents. The resulting molecules were thiophene, pyrazole, coumarin derivatives incorporated benzo[ d ]imidazole moiety. All the synthesized compounds were determined by elemental analysis, ¹H NMR, ¹³C NMR, and MS. The antitumor evaluations of the newly synthesized products toward the three cancer cell lines MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer), and SF-268 (CNS cancer) showed that compounds 5a , 9b , 9c , 17 , 23b and 38 were of the highest potencies among the synthesized compounds.

【 授权许可】

Unknown