期刊论文详细信息
The British Journal of Nutrition
Diets high in n-3 fatty acids are associated with lower arterial stiffness in patients with rheumatoid arthritis: a latent profile analysis
Richard J. Woodman^11  Jonathan M. Hodgson^42  Leena R. Baghdadi^23  E. Michael Shanahan^34  Inushi de Silva^15 
[1]Centre for Epidemiology and Biostatistics,College of Medicine and Public Health,Flinders University,Sturt Road, Bedford Park, Adelaide, SA 5042,Australia^1
[2]Department of Clinical Pharmacology,College of Medicine and Public Health,Flinders University and Flinders Medical Centre,GPO Box 2100, Adelaide, SA 5001,Australia^5
[3]Department of Family and Community Medicine,King Saud University,Riyadh 12372,Saudi Arabia^2
[4]Department of Rheumatology,Flinders University and Southern Adelaide Local Health Network,GPO Box 2100, Adelaide, SA 5001,Australia^3
[5]School of Medical and Health Sciences,Edith Cowan University,270 Joondalup Drive, Joondalup, WA 6027,Australia^4
关键词: Latent profile analysis;    Augmentation index;    n-3 Fatty acids;    Rheumatoid arthritis;   
DOI  :  10.1017/S0007114518003100
Subject:61.3
来源: Cambridge University Press
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【 摘 要 】
Supplementation with n -3 fatty acids can influence inflammation and markers of arterial stiffness that are increased in patients with rheumatoid arthritis (RA). However, it is unknown whether specific patterns of dietary fatty acid intake are similarly associated. In a longitudinal study, eighty-six RA patients reported their dietary intake and had arterial stiffness measured using the augmentation index (AIx) at baseline and 8 months. Latent profile analysis (LPA) was performed to characterise patterns of fatty acid intake using sixteen major fatty acids. Models for two to six profiles were compared using the Akaike and Bayesian information criteria. Associations between AIx and the profiles were adjusted for age, sex, disease activity, fish oil supplementation, medications, physical activity and socio-economic status. LPA identified five distinct profiles. Profile 1 subjects ( n 7) reported significantly higher intake of palmitoleic acid (16 : 1), arachidonic acid (20 : 4 n -6), EPA (20 : 5 n -3), DHA (22 : 6 n -3) and docosapentaenoic acid (22 : 5 n -3) ( P 0·001 for each) than profiles 2 ( n 14), 3 ( n 19), 4 ( n 23) and 5 ( n 23) and significantly higher grilled and tinned fish consumption. The AIx varied significantly across the five profiles ( P =0·023); subjects in profile 1 had a significantly lower AIx than those in profile 3 ( β =–7·2 %; 95 % CI –11·5, –2·9; P =0·001) who had the lowest reported intake of n -3 fatty acids. Fish oil supplementation was also independently associated with lower AIx ( β =–4·15 %; 95 % CI –6·73, –1·56; P =0·002). A diet characterised by a higher reported intake of n -3 fatty acids, palmitoleic acid (16 : 1) and arachidonic acid (20 : 4 n -6) is associated with a lower AIx in RA patients.
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