Smoking-Related Diffuse Cystic Lung Disease

Chest: The Journal of Circulation, Respiration and Related Systems

Cristopher A. Meyer^4¹  Francis X. McCormack^1,2³  Kathryn A. Wikenheiser-Brokamp^5,6⁴  Nishant Gupta^1,2⁵  Thomas V. Colby^3⁶ 

[1] Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ^3;Department of Pathology & Laboratory Medicine, University of Cincinnati, Cincinnati, OH^6;Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, WI^4;Division of Pathology & Laboratory Medicine and Perinatal Institute, Division of Pulmonary Biology, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH^5;Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, Cincinnati, OH^1;Medical Service, Veterans Affairs Medical Center, Cincinnati, OH^2

关键词: DCLD;    diffuse cystic lung disease;    HRCT;    high-resolution CT;    LAM;    lymphangioleiomyomatosis;    PLCH;    pulmonary Langerhans cell histiocytosis;   

DOI  :  10.1016/j.chest.2018.02.027

学科分类：呼吸医学

来源: American College of Chest Physicians

【 摘 要 】

Exposure to cigarette smoke can lead to a variety of parenchymal lung diseases, including diffuse cystic lung diseases (DCLDs). Lymphangioleiomyomatosis (LAM) is the prototypical DCLD and has a characteristic appearance on high-resolution CT (HRCT). We present a series of four patients with DCLD on HRCT who were referred to our institution with a presumed diagnosis of LAM and who were found instead to have smoking-related injury of the small airways on histopathological analysis. We submit that cigarette smoke–induced small airway injury can present as DCLD on HRCT in a pattern that can mimic LAM. A detailed history of cigarette smoke exposure should be obtained in patients presenting with DCLD, and imaging features should not be used in isolation to establish a firm diagnosis of LAM.

【 授权许可】

CC BY