Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7-d, double-blind, randomised, placebo-controlled, cross-over trial

The British Journal of Nutrition

Eamon Dolan^2¹  Conor P. Kerley^1²  Philip E. James^3³ 

[1] Acute Stroke Unit,Department of Medicine for the Elderly,Connolly Hospital Blanchardstown,Dublin 15,Republic of Ireland^2;Respiratory and Sleep Diagnostics Department,Connolly Hospital,Blanchardstown,Dublin 15,Republic of Ireland^1;School of Health Sciences,Cardiff Metropolitan University,Llandaff Campus,Western Avenue,Cardiff CF5 2YB,UK^3

关键词: Dietary nitrate;    Nitrite;    Nitric oxide;    Hypertension;    Blood pressure;   

DOI  :  10.1017/S0007114518000144

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

Dietary nitrate has been shown to increase nitrate/nitrite levels and decrease blood pressure (BP) in multiple populations. There are few reports among hypertensives and these reports have provided conflicting evidence. We aimed to assess the effect of daily nitrate compared with placebo in subjects with uncontrolled hypertension (HTN). On day 0, hypertensives wore an ambulatory BP monitor (ABPM) for 24 h and blood was taken. Subjects were then randomised to 7-d nitrate-rich beetroot juice (NO3−) (12·9 mmol nitrate) followed by 7-d nitrate-depleted beetroot juice (0·5 mmol nitrate) or vice versa. ABPM and blood were assessed before and after both conditions. In all, twenty subjects with treated yet uncontrolled HTN entered and completed the trial (mean age=62·5 years, mean BMI=30·7 kg/m2). Baseline BP was 137/80 (sd 7/7) mmHg. Dietary nitrate was well tolerated and resulted in significantly increased plasma nitrite (P=0·0004) and decreased 24-h systolic BP and diastolic BP compared with placebo (−8 mmHg; P=0·012 and −4 mmHg; P=0·018, respectively). Our results support the existing data suggesting an anti-hypertensive effect of dietary nitrate in treated yet uncontrolled hypertensives. Targeted dietary strategies appear promising contributors to BP control.

【 授权许可】

CC BY