Does dietary nitrate say NO to cardiovascular ageing? Current evidence and implications for research

Proceedings of the Nutrition Society

Ammar W. Ashor^4^5¹  Blossom C.M. Stephan^3²  Mario Siervo^1³  Filippo Scialò^2⁴  Oliver M. Shannon^1⁵ 

[1]Department of Pharmacology,College of Medicine, Al-Mustansiriyah University,Baghdad,Iraq^5

[2]Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University,Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH,UK,^4

[3]Human Nutrition Research Centre, Institute of Cellular Medicine, Newcastle University,Leech Building, Framlington Place, Newcastle upon Tyne NE2 4HH,UK^1

[4]Institute for Cell and Molecular Biosciences, Campus for Ageing and Vitality, University of Newcastle,Newcastle upon Tyne NE4 5PL,UK^2

[5]Institute of Health and Society and Newcastle University Institute of Ageing, Newcastle University, Biomedical Research Building, Campus of Ageing and Vitality,Newcastle upon Tyne NE4 5PL,UK^3

关键词: Nitric oxide;    Nutrition;    Ageing;    Endothelial function;    Dietary nitrate;    CVD;   

DOI  :  10.1017/S0029665118000058

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

CVD are characterised by a multi-factorial pathogenesis. Key pathogenetic steps in the development of CVD are the occurrence of endothelial dysfunction and formation of atherosclerotic lesions. Reduced nitric oxide (NO) bioavailability is a primary event in the initiation of the atherosclerotic cascade. NO is a free radical with multiple physiological functions including the regulation of vascular resistance, coagulation, immunity and oxidative metabolism. The synthesis of NO proceeds via two distinct pathways identified as enzymatic and non-enzymatic. The former involves the conversion of arginine into NO by the NO synthases, whilst the latter comprises a two-step reducing process converting inorganic nitrate $({\rm NO}_3^ - )$ into nitrite and subsequently NO.

【 授权许可】

CC BY