Follicular regulatory T cell in atherosclerosis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Daniela Baptista^1¹ 

[1]Division of Cardiology Foundation for Medical Researches Department of Medicine Specialties Faculty of Medicine University of Geneva Geneva Switzerland^1

关键词: Atherosclerosis;    Regulatory B cells;    B cell;    Follicular T cell;   

DOI  :  10.1002/JLB.MR1117-469R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Atherosclerosis is a chronic inflammatory disease involving the infiltration of immune cells, such as monocytes/macrophages, neutrophils, T cells, and B cells, into the inner layer of vessel walls. T and B cell functions in the process of atherogenesis, as well as their mutual regulation, have been investigated but several aspects remain to be clarified. In the present review, we give a brief overview of the functions of follicular regulatory T cell (Tfr) on follicular T (Tfh) and B cell regulation related to atherosclerosis pathogenesis, including their influence on lymphangiogenesis and lipoprotein metabolism. We will also discuss their potential therapeutics properties in the resolution of established atherosclerotic lesions.

【 授权许可】

CC BY