Post-learning paradoxical sleep deprivation impairs reorganization of limbic and cortical networks associated with consolidation of remote contextual fear memory in mice

Sleep

Salin, Paul-Antoine^1,2¹  Le Barillier, Léa^1,2²  Meunier, David^2,3,4,5,6³  Rosier, Marius^1,2⁴  El Yacoubi, Malika^2⁵  Malleret, Gaël^1,2⁶ 

[1] CMO, Lyon Neuroscience Research Center, Lyon Cedex, France^6;Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche, Institut National de la Santé et de la Recherche Médicale (INSERM), Unité, France^2;Dycog, Lyon Neuroscience Research Center, CH Le Vinatier, Bron, France^3;Forgetting and Cortical Dynamics, Lyon Neuroscience Research Center, University Lyon, Lyon, France^1;IMPACT, Lyon Neuroscience Research Center, Bron Cedex, France^4;NEUROPAIN, Lyon Neuroscience Research Center, Hôpital Neurologique, Bron Cedex, France^5

关键词: graph theoretical analysis;    immediate early gene;    prefrontal cortex;    post-traumatic stress disorder (PTSD);    systemic consolidation;   

DOI  :  10.1093/sleep/zsy188

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesParadoxical sleep (PS) has been shown to play an important role in memory, in particular in emotional memory processes. However, the involvement of this particular sleep stage in the systemic consolidation of remote (30 days old) memory has never been tested. We examined whether post-learning PS could play a role in the consolidation of remote fearful memory and in the brain network reorganization that depends on it.

【 授权许可】

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