Detecting Adaptation with Genome-Scale Molecular Evolutionary Analysis: An Educational Primer for Use with “RNA Interference Pathways Display High Rates of Adaptive Protein Evolution in Multiple Invertebrates”

Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation

Brian P. Lazzaro^1¹ 

[1] Cornell Institute of Host-Microbe Interactions and Disease, Department of Entomology, Cornell University, Ithaca, New York 14853^1

关键词: adaptation;    antiviral;    coevolution;    host–pathogen;    natural selection;    RNAi;    transposable element;   

DOI  :  10.1534/genetics.118.301453

学科分类：医学（综合）

来源: Genetics Society of America

【 摘 要 】

Hosts and pathogens impose coevolutionary pressure on each other as pathogens strive to establish themselves and hosts seek to suppress infection. RNA interference (RNAi) is a mechanism by which cells repress viruses and transposable elements, thereby serving as a form of immune defense. Previous studies have shown that antiviral RNAi genes evolve extraordinarily quickly in the fruit fly Drosophila melanogaster , suggesting that they may adaptively coevolve with viruses and transposable elements. An article by Palmer and colleagues extends this observation to nematodes and multiple insects. Their article can be combined with this Primer to demonstrate the use of comparative genomics and molecular evolutionary analyses in the measurement of natural selection. Related article in GENETICS : Palmer, W. H., J. D. Hadfield, and D. J. Obbard, 2018 RNA-Interference pathways display high rates of adaptive protein evolution in multiple invertebrates. Genetics 208: 1585–1599 .

【 授权许可】

CC BY