Response to chronic sleep restriction, extension, and subsequent total sleep deprivation in humans: adaptation or preserved sleep homeostasis?

Sleep

Skorucak, Jelena^1,2,3¹  Arbon, Emma L^4²  Achermann, Peter^1,2,3³  Dijk, Derk-Jan^4⁴ 

[1] Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland^1;Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland^2;Surrey Sleep Research Centre, University of Surrey, Guildford, United Kingdom^4;Zurich Center for Interdisciplinary Sleep Research, University of Zurich, Zurich, Switzerland^3

关键词: chronic sleep restriction;    chronic sleep extension;    sleep deprivation;    homeostasis;    allostasis;    Process S;    simulations;    adaptation;   

DOI  :  10.1093/sleep/zsy078

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Sleep is regulated by a homeostatic process which in the two-process model of human sleep regulation is represented by electroencephalogram slow-wave activity (SWA). Many studies of acute manipulation of wake duration have confirmed the precise homeostatic regulation of SWA in rodents and humans. However, some chronic sleep restriction studies in rodents show that the sleep homeostatic response, as indexed by SWA, is absent or diminishes suggesting adaptation occurs. Here, we investigate the response to 7 days of sleep restriction (6 hr time in bed) and extension (10 hr time in bed) as well as the response to subsequent total sleep deprivation in 35 healthy participants in a cross-over design. The homeostatic response was quantified by analyzing sleep structure and SWA measures. Sleep restriction resulted primarily in a reduction of rapid eye movement (REM) sleep. SWA and accumulated SWA (slow-wave energy, SWE) were not much affected by sleep extension/restriction. The SWA responses did not diminish significantly in the course of the intervention and did not deviate significantly from the predictions of the two-process model. The response to total sleep deprivation consisted of an increase in SWA and rise rate of SWA and SWE and did not differ between the two conditions. The data show that changes in sleep duration within an ecologically relevant range have a marked effect on REM sleep and that SWA responds in accordance with predictions based on a saturating exponential increase during wake and an exponential decline in sleep of homeostatic sleep pressure during both chronic sleep restriction and extension.

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