Insight on the regulation of chemokine activities

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

Valentina Cecchinato^1¹ 

[1]Laboratory of “Chemokines in Immunity” Institute for Research in Biomedicine Università della Svizzera italiana Bellinzona Switzerland^1

关键词: cell trafficking;    chemokines;    T‐helper cells;    viral infection;   

DOI  :  10.1002/JLB.3MR0118-014R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

The activity of chemokines is regulated by several mechanisms that control the final cellular response. The present review discusses the complexity of the regulation of the chemokine system, and the novel findings describing how in persistent infections, the expression of chemokine receptors on the surface of T cells does not correlate with their homing potential. Thanks to the latest advances in our comprehension of the chemokine system, novel approaches targeting chemokines, chemokine receptors, or protein of their signaling pathway should be considered in order to achieve a personalized therapy.

【 授权许可】

CC BY