Effects of polypropylene carbonate coating on the degradation and biocompatibility of degradable magnesium alloy AZ31

Estonian Academy of Sciences. Proceedings

Zhiwei Zhao¹ 

关键词: magnesium alloy;    biodegradability;    polymer coating;    corrosion;    biocompatibility;    orthopaedic implant.;   

DOI  :  10.3176/proc.2019.1.07

学科分类：化学（综合）

来源: Teaduste Akadeemia Kirjastus

【 摘 要 】

The use of magnesium alloys as degradable orthopaedic implants is limited by their rapid degradation in vivo andconsequent loss of mechanical integrity before sufficient bone healing has occurred. To address this limitation, we coated thesurface of AZ31 magnesium alloys with polypropylene carbonate (PPC). The obtained PPC-coated AZ31 showed reduced surfaceroughness, hardness, and hydrophilicity compared with bare AZ31. The PPC coating also significantly slowed the degradation ofAZ31 in a simulated body fluid. The adherence and proliferation of MC3T3 osteoblastic cells cultured on PPC-coated AZ31samples demonstrated good biocompatibility. The results of the present study indicate that application of a PPC coating mayextend the functional period of AZ31 magnesium implants in vivo to allow sufficient time for bone healing and for the stimulationof new bone formation.

【 授权许可】

CC BY-NC