Recognizable clinical subtypes of obstructive sleep apnea across international sleep centers: a cluster analysis

Sleep

Keenan, Brendan T^1¹  Bittencourt, Lia^4²  Arnardottir, Erna Sif^8,9³  McArdle, Nigel^3⁴  Magalang, Ulysses J^7⁵  Chen, Ning-Hung^5⁶  Mindel, Jesse W^7⁷  Benediktsdottir, Bryndis^8,9⁸  Prochnow, Lisa Kristin^10⁹  Cistulli, Peter A^6^1,10  Kim, Jinyoung^1,2^1,11  Singh, Bhajan^3^1,12 

[1] Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, PA^1;Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, Brazil^4;Department of Pulmonary Medicine, Agaplesion Bethesda Krankenhaus Wuppertal, Wuppertal, Germany^11;Department of Sleep, Landspitali University Hospital, Reykjavik, Iceland^8;Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, The Ohio State University Wexner Medical Center, Columbus, OH^7;Division of Pulmonary, Critical Care, and Sleep Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan^5;Faculty of Medicine, University of Iceland, Reykjavik, Iceland^9;Interdisciplinary Center of Sleep Medicine, Charité University Hospital, Berlin, Germany^10;Pulmonary, Critical Care and Sleep Disorder Center, Korea University Medical Center Ansan Hospital, Seoul, South Korea^12;Royal North Shore Hospital, Northern Clinical School, and Charles Perkins Centre University of Sydney, Australia^6;School of Nursing, University of Pennsylvania, Philadelphia, PA^2;Sir Charles Gairdner Hospital, Western Australian Sleep Disorders Research Institute, Nedlands, Western Australia, Australia^3

关键词: obstructive sleep apnea;    disease subtypes;    personalized medicine;    excessive sleepiness;    insomnia;    minimally symptomatic;   

DOI  :  10.1093/sleep/zsx214

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesA recent study of patients with moderate–severe obstructive sleep apnea (OSA) in Iceland identified three clinical clusters based on symptoms and comorbidities. We sought to verify this finding in a new cohort in Iceland and examine the generalizability of OSA clusters in an international ethnically diverse cohort.

【 授权许可】

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