Reboxetine and hyoscine butylbromide improve upper airway function during nonrapid eye movement and suppress rapid eye movement sleep in healthy individuals

Sleep

Wellman, Andrew^3,4¹  Grunstein, Ron^5,6²  Lim, Richard^1,2³  Carberry, Jayne C^1,2⁴  Eckert, Danny J^1,2⁶ 

[1] Division of Sleep Medicine, Brigham and Women’s Hospital, Boston, MA^3;Harvard Medical School, Boston, MA^4;Neuroscience Research Australia (NeuRA), Sydney, Australia^1;School of Medical Sciences, University of New South Wales, Sydney, Australia^2;Sydney Medical School, University of Sydney, Sydney, Australia^6;Woolcock Institute of Medical Research, Sydney, Australia^5

关键词: obstructive sleep apnea;    norepinephrine reuptake inhibitor;    muscarinic antagonists;    genioglossus;    tensor palatini;    upper airway physiology;    sleep-disordered breathing;   

DOI  :  10.1093/sleep/zsy261

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesRecent findings indicate that noradrenergic and antimuscarinic processes are crucial for sleep-related reductions in pharyngeal muscle activity. However, there are few human studies. Accordingly, this study aimed to determine if a combined noradrenergic and antimuscarinic intervention increases pharyngeal dilator muscle activity and improves airway function in sleeping humans.

【 授权许可】

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