Risk factors for human Mycobacterium bovis infections in an urban area of Brazil

Memorias do Instituto Oswaldo Cruz

Araújo, Flábio Ribeiro^3^1,10  Fonseca-Júnior, Antônio Augusto^4^2,25  Guimarães, Mark Drew Crosland^7^3,37  Moreira, Maria Aparecida Scatamburlo^6^4,47  Suffys, Philip Noel^2^8,86  Rocha, Adalgiza da Silva^2^1,12,129  Costa, Ronaldo Rodrigues da^5^1,14,148  Alencar, Andrea Padilha de^4^1,15,152  Silva, Marcio Roberto^1^2,21,210 

[1] Queen's University, Centre for Health Services and Policy Research^285;Queen’s University, School of Geography and Urban and Regional Planning^283;Abertawe Bro Morgannwg University Health Board^216;Academic Medical Centre^279;Academic and Community Emergency Specialists^239;Aerodyne Research Inc, Billerica, MA 01821, USA^23;Albert Schweitzer Hospital^268;Amphia Hospital^267;Atmospheric Turbulence and Diffusion Division, ARL, National Oceanic and Atmospheric Administration, Oak Ridge, USA^66;Beilun Bureau of Meteorology, Ningbo 315800, China^3;British Geological Survey, Environmental Science Centre, Keyworth, Nottingham NG12 5GG, UK^94;Broad Institute, United States^148;Brock University^260;Brookhaven National Laboratory, Upton, NY, USA^18;Buenos Aires, Buenos Aires, Argentina^200;CAS Center for Excellence in Regional Atmospheric Environment, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361000, Fujian, China^29;CASP, West Building, Madingley Rise, Madingley Road, CB3 0UD, Cambridge, UK^38;Centers for Disease Control and Prevention, Atlanta, USA^108;Centre for Agriculture and Biosciences International, UK^183;Centro Científico Tecnológico La Plata, Buenos Aires, Argentina^160;Charles University, Prague, Czech Republic^204;China Center for Disease Control and Prevention, Beijing, China^110;Cleveland State University^235;Cold Regions Research Centre, Wilfrid Laurier University, Waterloo, Ontario, Canada^52;Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Nanjing University of Information Science & Technology, Nanjing 210044, China^4;College of Health Professions^228;College of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, China^30;College of Pharmacy^230;Complejo Hospitalario Universitario A Coruña, La Coruña, Spain^167;Consejo Nacional de Ciencia Y Tecnología, Zacatecas, México^192;Critical Care^256;Czech University of Life Sciences, Faculty of Environmental Sciences, Prague, Czech Republic^44;Delegación Territorial de AEMET (Spanish National Meteorological Agency) en Aragon, Zaragoza, Spain^75;Department of Anesthesia^254;Department of Animal Ecology & Systematics, Justus Liebig University, Heinrich-Buff-Ring 26–32 IFZ, 35392 Giessen, Germany^35;Department of Atmospheric Sciences and Department of Chemistry, Texas A&M University, College Station, TX 77843, USA^21;Department of Chemistry and Cooperative Institute for Research in Environmental Sciences, University of Colorado, Boulder, CO, USA^9;Department of Child and Adolescent Psychiatry^226;Department of Civil and Environmental Engineering, Imperial College London, London, UK^63;Department of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, CA, USA^12;Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, Ontario, Canada^56;Department of Clinical and Health Psychology^219;Department of Earth Sciences, Western University, London, Ontario, Canada^61;Department of Earth and Planetary Sciences, Harvard University, Cambridge, MA, USA^20;Department of Environment, Water and Natural Resources, Government of South Australia, Adelaide, SA 5000, Australia^101;Department of Environmental Science, Policy, and Management, University of California, Berkeley, CA, USA^11;Department of Environmental Sciences, Universidade Federal de São Paulo, Diadema, São Paulo, Brazil^8;Department of Geography, University of Guelph, Guelph, Ontario, Canada^53;Department of Geography, University of Innsbruck, Innsbruck, Austria^95;Department of Geography, University of Lethbridge, Lethbridge, Alberta, Canada^55;Department of Geology, Faculty of Geology and Geophysics, University of Bucharest, Bălcescu Bd. 1, 010041 Bucharest, Romania^37;Department of Geology, University of Namur, Rue de Bruxelles 61, 5000 Namur, Belgium^93;Department of Geoscience, University of Calgary, Calgary, Alberta, Canada^57;Department of Geosciences and Engineering, Delft University of Technology, Stevinweg 1, 2628 CN Delft, the Netherlands^41;Department of Geosciences, University of Oslo, P.O. Box 1022 Blindern, 0315 Oslo, Norway^84;Department of Hydrology and Atmospheric Sciences, University of Arizona, Tucson, AZ, USA^46;Department of Medicine^261;Department of Pharmacy^232;Department of Psychiatry^262;Department of Quality and Patient Safety^253;Department of Radiation Oncology^217;Department of Renewable Resources, University of Alberta, Edmonton, Alberta, Canada^58;Department of Statistics, University of Innsbruck, Innsbruck, Austria^106;Department of Statistics^247;Dipartimento di Ingegneria Civile, Ambientale e Architettura, Università di Cagliari, Cagliari, Italy^80;Dipartimento di Matematica e Informatica, Università di Cagliari, Cagliari, Italy^81;Direction Home Area Agency on Aging and Disabilities^246;Division for Biomedical Physics, Medical University of Innsbruck, Innsbruck, Austria^105;Division of Geological and Planetary Sciences, California Institute of Technology, Pasadena, CA 91125, USA^25;Duke University Health System^213;Duke University School of Medicine, Durham, USA^156;Duke University, Durham, USA^151;Dép. Biologie, Chimie et Géographie, groupe BOREAS and Québec-Océan, Université du Québec à Rimouski, 300 allée des ursulines, Rimouski, Qc, G5L 3A1, Canada^88;Département de Géographie and Centre d'études nordiques, Université de Montréal, Montréal, Quebec, Canada^62;ENVEO IT GmbH, Innsbruck, Austria^98;EPOC, UMR 5805, Université de Bordeaux, Allée Geoffroy Saint-Hilaire, 33615 Pessac, France^85;Embrapa Gado de Corte, Campo Grande, Brasil^292;Embrapa Gado de Leite, Juiz de Fora, Brasil^291;Emergency Medicine^238;Endocrinology Department^223;Environment Research Institute, Shandong University, Qingdao 266237, China^24;Environment and Climate Change Canada, Saskatoon, Canada^73;Environment and Climate Change Canada, Toronto, Canada^67;Environment and Climate Change Canada, Victoria, Canada^74;Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA^19;Environmental and Climate Sciences Department, Brookhaven National Laboratory, Upton, New York 11973-5000, USA^6;Erasmus Medical Centre^269;Faculty of Physics and Electrical Engineering, University of Bremen, Bremen, Germany^50;Family Medicine^248;Family and Community Medicine^241;Flinders University Faculty of Medicine, School of Health Sciences^250;Fundação Municipal de Saúde de Teresina, Teresina, Brasil^211;Fundação Oswaldo Cruz, Curitiba, Brasil^208;Fundação Oswaldo Cruz, Manaus, Brasil^123;Fundação Oswaldo Cruz, Recife, Brasil^286;Fundação Oswaldo Cruz, Rio de Janeiro, Brasil^207;Fundação Oswaldo Cruz-Fiocruz, Belo Horizonte, Brasil^127;Fundação Oswaldo Cruz-Fiocruz, Manaus, Brasil^182;Fundação Oswaldo Cruz-Fiocruz, Porto Velho, Brasil^168;Fundação Oswaldo Cruz-Fiocruz, Recife, Brasil^197;Fundação Oswaldo Cruz-Fiocruz, Rio de Janeiro, Brasil^113;Fundação Oswaldo Cruz-Fiocruz, Salvador, Brasil^139;Fundação Oswaldo Cruz-Fiocruz-Fiocruz, Manaus, Brasil^172;Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, Brasil^115;GET-GRGS, UMR 5563, CNRS/IRD/UPS, Observatoire Midi-Pyrénées, 31400 Toulouse, France^86;GHD Canada, Waterloo, Ontario, Canada^54;Geology and Applied Geology Unit, Faculty of Engineering, University of Mons, Place du Parc 20, 7000 Mons, Belgium^89;Georgikon Faculty, University of Pannonia, Deák Ferenc u. 16, 8360 Keszthely, Hungary^48;Grantham Institute – Climate Change and the Environment, Imperial College London, London, UK^64;Grigore Antipa National Museum of Natural History, Sos. Kiseleff Nr. 1, 011341 Bucharest, Romania^39;Groundwater and Quaternary Geology Mapping Department, Geological Survey of Denmark and Greenland, Aarhus, Denmark^82;Guangzhou Key Laboratory Environmental Catalysis and Pollution Control, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou 510006, China^22;HR Wallingford, Howbery Park, Wallingford, Oxfordshire OX10 8BA, UK^65;Haaglanden Medical Centre^273;Harvard, Cambridge, USA^149;Hospital Geral de Nova Iguaçu, Nova Iguaçu, Brasil^126;Hospital Otávio de Freitas, Recife, Brasil^289;Hospital Regional João Penido, Juiz de Fora, Brasil^294;Howard University, Washington DC, United States of America^138;Humber River Hospital^252;Imperial College London, London, United Kingdom^150;Infectious Disease Research Institute, Seattle, USA^203;Institut Pasteur de la Guyane, Cayenne, French Guiana^199;Institut Pasteur, Paris, France^147;Institute for Soil Sciences and Agricultural Chemistry, Centre for Agricultural Research, Hungarian Academy of Sciences, Herman Ottó út 15, 1022 Budapest, Hungary^47;Institute of Atmospheric and Cryospheric Sciences, University of Innsbruck, Innsbruck, Austria^103;Institute of Hydrology and Water Resources Management, Leibniz Universität Hannover, Hannover, Germany^97;Institute of Physics, University of São Paulo, São Paulo, Brazil^14;Institute of Urban Meteorology, China Meteorological Administration, Beijing 100089, China^2;Instituto Adolfo Lutz, São Paulo, Brasil^122;Instituto Evandro Chagas, Ananindeua, Brasil^143;Instituto Federal de Ciência e Tecnologia do Sertão Pernambucano, Brasil^288;Instituto Mexicano del Seguro Social, Guadalupe, México^194;Instituto Mexicano del Seguro Social, Monterrey, México^164;Instituto Mexicano del Seguro Social, Zacatecas, Mexico^189;Instituto Nacional de Ciencias Médicas y de la Nutrición Salvador Zubirán, Ciudad de México, México^191;Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, Brasil^186;Instituto Nacional de Câncer, Rio de Janeiro, Brasil^290;Instituto Nacional de Medicina Tropical, Puerto Iguazú, Argentina^159;Instituto Nacional de Salud, Bogotá, Colombia^155;Instituto de Biologia Molecular do Paraná, Curitiba, Brasil^209;Instituto de Salud Carlos III, Madrid, Spain^157;Integrated Water Systems and Governance, IHE Delft, Delft, the Netherlands^76;Internal Medicine Department^221;Internal Medicine^212;Invited contribution by Arnaud Watlet, recipient of the EGU Hydrological Sciences Outstanding Student Poster and PICO Award 2016^91;Isala Clinics^281;John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA^7;Kansas Geological Survey, University of Kansas, Lawrence, KS 66047, USA^102;Karst Research Institute ZRC SAZU, Titov trg 2, 6230 Postojna, Slovenia^51;Key Lab. of Environmental Optics and Technology, Anhui Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Hefei 230031, China^26;Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration, School of Atmospheric Physics, Nanjing University of Information Science & Technology, Nanjing 210044, China^5;Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea^100;LEGOS-GRGS, UMR 5566, CNRS/IRD/UPS, Observatoire Midi-Pyrénées, 31400 Toulouse, France^87;Laboratoire de Planétologie et Géodynamique – Nantes (LPGN), UFR Sciences et Techniques, Université de Nantes, UMR-CNRS 6112, Rue de la Houssinière 2, BP92208, 44322 Nantes CEDEX 3, France^92;Leiden University Medical Centre^274;LuftBlick, Innsbruck, Austria^104;Maastricht University Medical Centre^271;McMaster University^259;Mediterranean Agronomic Institute (MAIB) – Land and Water Department, Valenzano (Bari), Italy^78;Meteorological Service of Canada, Environment and Climate Change Canada, Dartmouth, Canada^71;Meteoswiss, Payerne, Switzerland^72;Ministerio de Salud, Santiago, Chile^118;Ministério da Agricultura, Pecuária e Abastecimento, Pedro Leopoldo, Brasil^293;Ministério da Saúde, Brasília, Brasil^205;NIOZ Royal Netherlands Institute for Sea Research, Department of Ocean Systems, 1790 AB Den Burg, the Netherlands^40;Nacional Colonia La Campaña, Tegucigalpa, Honduras^111;National Center For Atmospheric Research, Research Application Laboratory, Boulder, CO, USA^42;National Center for Atmospheric Research, Boulder, USA^70;National Centre for Groundwater Research and Training, School of the Environment, Flinders University, Adelaide, SA 5001, Australia^99;National Hydrology Research Centre, Saskatoon, Saskatchewan, Canada^59;National Institute of Marine Geology and Geoecology (GeoEcoMar), 23–25 Dimitrie Onciul St., 024053 Bucharest, Romania^36;Naturalis Biodiversity Center, P.O. Box 9517, 2300 RA Leiden, the Netherlands^32;Neonatal Unit^215;Niagara Health^255;Niagara Regional Campus, Michael G DeGroote School of Medicine^258;Northeastern Ohio Medical University^231;Northwest Clinics^277;Norwegian Meteorological Institute, Oslo, Norway^69;Palaeomagnetic Laboratory “Fort Hoofddijk”, Faculty of Geosciences, Utrecht University, Budapestlaan 17, 3584 CD Utrecht, the Netherlands^34;Palliative and Supportive Services^249;Pan American Health Organization, Washington DC, USA^112;Pediatrics^214;Planning and Quality Improvement^245;Professional Practice^251;Queen's University, Centre for Health Services and Policy Research^282;Queen’s University, School of Rehabilitation Therapy^284;Queen’s University^263;Radboud University Medical Centre^272;Rede Proteômica do Rio de Janeiro, Rio de Janeiro, Brasil^174;School of Counseling^244;School of Environmental Science and Optoelectronic Technology, University of Science and Technology of China, Hefei 230027, China^28;School of Health Sciences^234;School of Mathematics and Physics, Anhui University of Technology, Ma'anshan 243032, China^31;School of Nursing^243;School of Social Work^242;Science Island Branch of Graduate School, University of Science and Technology of China, Hefei 230026, China^27;Secretaria de Estado da Saúde de São Paulo, São Paulo, Brasil^142;Secretaria de Estado da Saúde do Espírito Santo, Vitória, Brasil^135;Secretaria de Estado da Saúde do Piauí, Teresina, Brasil^210;Section of Endocrinology, Internal Medicine Department^224;Seismology-Gravimetry, Royal Observatory of Belgium, Avenue Circulaire 3, 1180 Uccle, Belgium^90;Senior Administration^257;Senior Health^240;Seniors Institute Research^236;South London and Maudsley NHS Foundation Trust^227;Southern Illinois University Carbondale, Carbondale, USA^120;Southern Illinois University, Carbondale, USA^119;St Antonius Hospital^278;State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China^1;State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan 430072, P.R. China^83;Summa Health System^237;Summa Health^233;Superintendência de Controle de Endemias, São Paulo, Brasil^136;The University of Akron^229;These authors contributed equally to this work^33;Tropical Medicine Institute Pedro Kourí, Havana, Cuba^154;UFZ-Helmholtz Centre for Environmental Research, Department of Computational Hydrosystems, Leipzig, Germany^43;Universidad Anahuac, Mexico Norte, Mexico^196;Universidad Autónoma de Madrid, Madrid, Spain^166;Universidad Autónoma de Nuevo León, Monterrey, México^165;Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico^190;Universidad Metropolitana de Ciencias de la Educación, Santiago, Chile^117;Universidad Nacional Autónoma de México, Ciudad de Mexico, Mexico^195;Universidad Nacional de Asunción, Asunción, Paraguay^162;Universidad de Chile, Santiago, Chile^116;Universidad de Pamplona, Cúcuta, Colombia^153;Universidad de la República, Montevideo, Uruguay^161;Universidad de la República, Paysandú, Uruguay^163;Universidade Estadual Paulista, Araraquara, Brasil^176;Universidade Estadual Paulista, Botucatu, Brasil^181;Universidade Estadual Paulista, Jaboticabal, Brasil^178;Universidade Estadual Paulista, Rio Claro, Brasil^179;Universidade Estadual de Londrina, Londrina, Brasil^141;Universidade Estadual do Sudoeste da Bahia, Jequié, Brasil^132;Universidade Federal Fluminense, Niterói, Brasil^140;Universidade Federal de Juiz de Fora, Governador Valadares, Brasil^202;Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil^188;Universidade Federal de Minas Gerais, Belo Horizonte, Brasil^131;Universidade Federal de Pelotas, Capão do Leão, Brasil^144;Universidade Federal de Pelotas, Pelotas, Brasil^129;Universidade Federal de Pernambuco, Recife, Brasil^287;Universidade Federal de Rondônia, Porto Velho, Brasil^170;Universidade Federal de Sergipe, Aracaju, Brasil^137;Universidade Federal de São Carlos, São Carlos, Brasil^180;Universidade Federal de São João Del-Rei, Divinópolis, Brasil^169;Universidade Federal de Viçosa, Viçosa, Brasil^184;Universidade Federal do Amazonas, Manaus, Brasil^171;Universidade Federal do Espírito Santo, Vitória, Brasil^134;Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brasil^125;Universidade Federal do Paraná, Curitiba, Brasil^206;Universidade Federal do Pará, Belém, Brasil^145;Universidade Federal do Rio Grande do Norte, Natal, Brasil^201;Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil^128;Universidade Federal do Rio de Janeiro, Duque de Caxias, Brasil^175;Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil^124;Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina, Brasil^133;Universidade de Brasília, Brasília, Brasil^107;Universidade de Pernambuco, Recife, Brasil^198;Universidade de São Paulo, São Carlos, Brasil^177;Universidade de São Paulo, São Paulo, Brasil^130;Universidade do Estado do Amazonas, Manaus, Brasil^114;Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil^146;University Hospital Essen^265;University Hospital of Giessen and Marburg, Standort Giessen^280;University Medical Centre Groningen^276;University Medical Centre Utrecht^275;University of Amsterdam^264;University of Basilicata, School of Agricultural, Forestry and Environmental Sciences – Hydraulics and Hydrology Division, Potenza, Italy^79;University of Birmingham, Edgbaston, UK^158;University of Florida College of Medicine^218;University of Florida College of Public Health and Health Professions^220;University of Geneva, Geneva, Switzerland^187;University of Ghana, Legon, Ghana^109;University of Leeds, Leeds, UK^173;University of Ostrava, Ostrava, Czech Republic^185;University of Sydney, Sydney, Australia^152;Université Paul Sabatier, Toulouse, France^193;VU Medical Centre^270;Water Institute and Department of Earth and Environmental Sciences, University of Waterloo, Waterloo, Ontario, Canada^60;Water Resources Section, Delft University of Technology, Delft, the Netherlands^77;Wegener Center for Climate and Global Change, University of Graz, Graz, Austria^96;Western Kentucky University, Bowling Green, USA^121;World Meteorological Organization, Geneva, Switzerland^68;Yale New Haven Health Bridgeport Hospital^222;Yale School of Medicine^225;now at: Agrarian Sciences Institute, Federal University of Uberlândia, Minas Gerais, Brazil^16;now at: Coldwater Laboratory, University of Saskatchewan, Canmore, Alberta, Canada^45;now at: College of Environmental Science and Engineering, Peking University, Beijing, China^17;now at: Department of Atmospheric Sciences, University of Washington, Seattle, WA, USA^10;now at: Department of Civil and Environmental Engineering, Virginia Tech, Blacksburg, VA, USA^13;now at: IMT Lille Douai, Université Lille, SAGE, Lille, France^15;previously published under the name Tóth^49;‘Carol Davila’ University of Medicine and Pharmacy^266

关键词: tuberculosis;    zoonoses;    risk factors;   

DOI  :  10.1590/0074-02760170445

学科分类：地质学

来源: Bioline International

【 摘 要 】

BACKGROUND The World Health Organization (WHO) has classified human zoonotic tuberculosis (TB) due to Mycobacterium bovis as a neglected issue in the developing world. In a recent cross-sectional study in Brazil, three of 189 TB patients presented with a coinfection of M. bovis and M. tuberculosis and were selected as cases for this study. OBJECTIVE The aim was to evaluate risk factors (RF) for zoonotic TB in an urban area of Brazil in order to guide preventive programmes. METHODS A matched case-control study was carried out nested within a cross-sectional study. For each of the three cases, 14 age- and sex-matched controls (TB due to M. tuberculosis) were selected. FINDINGS Zoonotic potential exposures (ZE) and extrapulmonary TB (EPTB) were independently associated with zoonotic TB in multivariate analyses. CONCLUSIONS ZE by occupation and consumption of raw milk and derivative products that place individuals in direct and indirect contact with animals and their excretions/secretions increase the risk for zoonotic TB in Brazil, especially among those with EPTB. Therefore, measures such as efficient control of bovine TB, distribution of pasteurised milk and its derivative products, and the diagnosis and monitoring of zoonotic TB in humans are essential steps, especially in developing countries where bovine TB is enzootic, and further studies are necessary.

【 授权许可】

Free