Effect of suvorexant on event-related oscillations and EEG sleep in rats exposed to chronic intermittent ethanol vapor and protracted withdrawal

Sleep

Sanchez-Alavez, Manuel^1¹ 

[1] Department of Neurosciences, The Scripps Research Institute, La Jolla, CA^1

关键词: alcohol;    EEG;    event-related oscillations;    suvorexant;    slow-wave sleep;   

DOI  :  10.1093/sleep/zsz020

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesInsomnia is a prominent complaint in patients with alcohol use disorders (AUD). However, despite the importance of sleep in the maintenance of sobriety, treatment options for sleep disturbance associated with a history of AUD are currently limited. Recent clinical trials have demonstrated that suvorexant, a dual Hct/OX receptor antagonist, normalizes sleep in patients with primary insomnia; yet, its potential for the treatment of sleep pathology associated with AUD has not been investigated in either preclinical or clinical studies.

【 授权许可】

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