Scaled-up preparation of drug-loaded electrospun polymer fibres and investigation of their continuous processing to tablet form

eXPRESS Polymer Letters

E. Szabo¹ 

关键词: industrial applications;    high speed electrospinning;    amorphous solid dispersions;    tableting;    continuous processing;    technologies;   

DOI  :  10.3144/expresspolymlett.2018.37

学科分类：生物科学（综合）

来源: eXPRESS Polymer Letters

【 摘 要 】

Polymer-based electrospun amorphous solid dispersions (ASDs) were prepared and investigated from pharmaceuticalapplication point of view. Spironolactone (SPIR) was used as model drug mixed in various concentrations withpolymers suitable for fibre formation, such as vinylpyrrolidone-vinyl acetate copolymer, polyvinylpyrrolidone K30 and hydroxypropylmethylcellulose. Single needle electrospinning was applied at first for screening the composition of the preparedASDs. Scaling-up the selected polymer-drug combination was accomplished by high speed electrospinning, the productivityof which enabled investigation of downstream processing to generate tablet formulation. The steps of a potential continuousproduction line (fibre collection, grinding, feeding and tableting) proved to be feasible with the electrospun ASD withoutany sign of crystallization. If crystalline drug was added into the ASD containing tablets as impurity strictly monotonousdecrease of drug dissolution was observed in the function of the crystalline drug content. The capabilities of the non-destructiveRaman and near-infrared spectroscopies, as fast quality assurance tools, were compared to each other in quantifyingof crystalline SPIR content in the prepared tablets.

【 授权许可】

CC BY