Mouse Gambling Task reveals differential effects of acute sleep debt on decision-making and associated neurochemical changes

Sleep

Chennaoui, Mounir^1,3¹  Dorey, Rodolphe^1,3²  Callebert, Jacques^5³  Granon, Sylvie^2⁴  Pittaras, Elsa^1,2,3,4⁵ 

[1] Biology Department, Stanford University, Stanford, CA^4;Equipe d’accueil VIgilance FAtigue et SOMmeil (VIFASOM) EA 7330 - Université Paris 5 Descartes, Paris, France^3;Equipe ‘Neurobiologie de la prise de décision’, Neuro-PSI, CNRS UMR 9197, Orsay, France^2;Service de Biochimie et Biologie Moléculaire, Hôpital Lariboisière, Paris, France^5;Unité Fatigue et Vigilance, Département Environnements Opérationnels, Institut de Recherche Biomédicale des armées, Brétigny-sur-Orge cedex, France^1

关键词: sleep;    decision-making;    interindividual differences;    brain;    monoamines;    dorsal striatum;    frontal cortex;    sleep deprivation;   

DOI  :  10.1093/sleep/zsy168

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Sleep loss is associated with sleepiness, sustained attention, and memory deficits. However, vulnerability of higher cognitive processes (i.e. decision making) to sleep debt is less understood. Therefore, a major challenge is to understand why and how higher cognitive processes are affected by sleep debt. We had established in mice correlations between individual decision-making strategies, prefrontal activity, and regional monoaminergic levels. Now, we show that acute sleep debt (ASD) disturbs decision-making processes and provokes brain regional modifications of serotonin and dopamine that could explain why ASD promotes inflexible and more risk-prone behaviors. Finally, we highlight, for the first time, that in a large group of healthy inbred mice some of them are more sensitive to ASD by showing inflexible behavior and decision-making deficits. We were also able to predict mice that would be the most vulnerable to ASD depending of their behavior before ASD exposure.

【 授权许可】

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