Objective sleep duration is associated with cognitive deficits in primary insomnia: BDNF may play a role

Sleep

Chen, Wen-Hao^1¹  Fan, Teng-Teng^1²  Shi, Le^1,2³  Lin, Xiao^1,3⁴ 

[1] National Institute on Drug Dependence and Beijing Key laboratory of Drug Dependence Research, Peking University, Beijing, China^2;Peking University Sixth Hospital, Peking University Institute of Mental Health, Key Laboratory of Mental Health, Ministry of Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China^1;Peking-Tsinghua Center for Life Sciences and PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China^3;Sleep Medicine Center, West China Hospital, Sichuan University, Sichuan 610041, China^4

关键词: insomnia;    polysomnography;    BDNF;    cognitive function;    neuropsychological performance;    short sleep duration;   

DOI  :  10.1093/sleep/zsy192

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesObjective sleep duration has been linked to insomnia severity. However, cognitive functions of people with insomnia with different sleep durations have been seldom addressed. Brain-derived neurotrophic factor (BDNF) has an important role in cognitive function and has been linked to clinical insomnia recently. The present study aimed to evaluate the comprehensive cognitive functions in people with primary insomnia with different objective sleep durations, and further examine the involvement of peripheral BDNF.

【 授权许可】

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