Invading, Leading and Navigating Cells in Caenorhabditis elegans: Insights into Cell Movement in Vivo

Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation

David R. Sherwood^1¹  Julie Plastino^2,3² 

[1] Department of Biology, Regeneration Next, Duke University, Durham, North Carolina 27705^1;Institut Curie, PSL Research University, CNRS, UMR 168, F-75005 Paris, France^2;Sorbonne Universités, UPMC Univ Paris 06, CNRS, UMR 168, F-75005 Paris, France^3

关键词: basement membrane;    C. elegans;    cell invasion;    cell migration;    cell signaling;    F-actin;    FGF pathway;    integrin;    netrin pathway;    Wnt pathway;    WormBook;   

DOI  :  10.1534/genetics.117.300082

学科分类：医学（综合）

来源: Genetics Society of America

【 摘 要 】

Highly regulated cell migration events are crucial during animal tissue formation and the trafficking of cells to sites of infection and injury. Misregulation of cell movement underlies numerous human diseases, including cancer. Although originally studied primarily in two-dimensional in vitro assays, most cell migrations in vivo occur in complex three-dimensional tissue environments that are difficult to recapitulate in cell culture or ex vivo . Further, it is now known that cells can mobilize a diverse repertoire of migration modes and subcellular structures to move through and around tissues. This review provides an overview of three distinct cellular movement events in Caenorhabditis eleganscell invasion through basement membrane, leader cell migration during organ formation, and individual cell migration around tissues—which together illustrate powerful experimental models of diverse modes of movement in vivo . We discuss new insights into migration that are emerging from these in vivo studies and important future directions toward understanding the remarkable and assorted ways that cells move in animals.

【 授权许可】

CC BY