Sex differences in measures of central sensitization and pain sensitivity to experimental sleep disruption: implications for sex differences in chronic pain

Sleep

Finan, Patrick H^1¹  Smith, Michael T^1²  Remeniuk, Bethany^1³ 

[1] Department of Psychiatry and Behavioral Sciences, Cousins Center for Psychoneuroimmunology, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA^3;Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD^1;Department of Psychiatry, UCSF School of Medicine, San Francisco, CA^2

关键词: sleep disruption;    pain sensitivity;    central sensitization;    sex differences;    temporal summation;    secondary hyperalgesia;    capsaicin;    chronic pain;    sex effects;   

DOI  :  10.1093/sleep/zsy209

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Study ObjectivesFemales demonstrate heightened central sensitization (CS), a risk factor for chronic pain characterized by enhanced responsivity of central nervous system nociceptors to normal or subthreshold input. Sleep disruption increases pain sensitivity, but sex has rarely been evaluated as a moderator and few experiments have measured CS. We evaluated whether two nights of sleep disruption alter CS measures of secondary hyperalgesia and mechanical temporal summation in a sex-dependent manner. We also evaluated differences in measures of pain sensitivity.

【 授权许可】

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