Time stability of laser exposed phenothiazines aqueous-solutions in view of antimicrobial research

Proceedings of the Romanian Academy Series A-Mathematics Physics Technical Sciences Information Science

Tatiana TOZAR¹ 

关键词: Chlorpromazine;    Thioridazine;    Time stability;    Laser exposure;    Absorption spectroscopy.;   

DOI  :  

学科分类：计算机科学（综合）

来源: Editura Academiei Romane

【 摘 要 】

Time-stability studies of two non-antibiotics, chlorpromazine and thioridazine, whichpossess antimicrobial activity after their exposure to UV pulsed laser beams, are reported. The role ofstability testing is to provide information about how the quality of such a drug varies over time, inview of further applications. The dynamics of identified peaks in absorption spectra shows anabsorption dependence of the new formed photoproducts with respect to irradiation time. Bothchlorpromazine and thioridazine irradiated solutions stabilize after 24 h and 48 h, respectively. Thesolutions are stable for different periods function of exposure time. Thus, the conclusions show thatthe samples are stable and can be used in antimicrobial susceptibility assays along one to four weeksafter irradiation, depending of irradiation time intervals.

【 授权许可】

Unknown