Social, motor, and cognitive development through the lens of sleep network dynamics in infants and toddlers between 12 and 30 months of age

Sleep

Lustenberger, Caroline^1,3¹  Page, Jessica^1,2⁵  Frӧhlich, Flavio^1,2,4,5,6,7⁶ 

[1] Carolina Center for Neurostimulation, University of North Carolina at Chapel Hill, Chapel Hill, NC^2;Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC^7;Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC^4;Department of Neurology, University of North Carolina at Chapel Hill, Chapel Hill, NC^6;Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC^1;Institute of Robotics and Intelligent Systems, Mobile Health Systems Lab, ETH Zurich, Zurich, Switzerland^3;Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, NC^5

关键词: development;    infants;    toddlers;    NREM;    sleep spindles;    slow waves;    fine motor;    social;    language;    θ;   

DOI  :  10.1093/sleep/zsy024

学科分类：生理学

来源: American Academy of Sleep Medicine

【 摘 要 】

Widespread change in behavior and the underlying brain network substrate is a hallmark of early development. Sleep plays a fundamental role in this process. Both slow waves and spindles are key features of nonrapid eye movement sleep (NREM) that exhibit pronounced developmental trajectories from infancy to adulthood. Yet, these prominent features of NREM sleep are poorly understood in infants and toddlers in the age range of 12 to 30 months. Moreover, it is unknown how network dynamics of NREM sleep are associated with outcomes of early development. Addressing this gap in our understanding of sleep during development will enable the subsequent study of pathological changes in neurodevelopmental disorders. The aim of the current study was to characterize the sleep topography with high-density electroencephalography in this age group. We found that δ, θ, and β oscillations and sleep spindles exhibited clear developmental changes. Low δ and high θ oscillations correlated with motor, language, and social skills, independent of age. These findings suggest an important role of network dynamics of NREM sleep in cortical maturation and the associated development of skills during this important developmental period.

【 授权许可】

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