Exosome-mediated cell-cell communication in tumor progression

American Journal of Cancer Research

Xiaotong Gao¹  Zhuo Wan²  Yan Dong³ 

[1] Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xian 710032, Shaanxi, China;Department of Hematology, Tangdu Hospital, Fourth Military Medical University, Xian 710038, Shaanxi, China;Department of Implantation, School of Stomatology, Fourth Military Medical University, Xian 710032, Shaanxi, China

关键词: Tumor microenvironment;    exosome;    metastasis;    chemoresistance;    proliferation;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

Exosomes, which are 30-150 nm lipid bilayer vehicles, have been recognized as one of the most crucial components of the tumor microenvironment. Exosomes transfer specific lipid, nucleic acids, proteins and other bioactive molecules from the donor cells to the recipient cells. Accumulating evidence has suggested that cancer cells and the tumor associated stromal cells can release and receive exosomes, inside of which the components and amounts are greatly changed. Pioneering studies have revealed that these exosomes play essential roles in tumor progression. Here we summarize the recent advances in this field, by focusing on the exosome biogenesis in the cancer condition, and their biological function in angiogenesis, metastasis and chemo-resistance of tumor. The review would not only provide a summary of this field, but also insights and perspectives on exosome-based strategies in cancer diagnoses, prevention and therapy.

【 授权许可】

CC BY-NC