Positive and Negative Syndrome Scale (PANSS) Training: Challenges, Solutions, and Future Directions

Innovations in Clinical Neuroscience

David G. Daniel¹  Mark G.A. Opler²  Christian Yavorsky³ 

[1] Dr. Daniel is Chief Medical Director and Senior Vice President of Bracket Global, LLC and Clinical Professor at George Washington University, in Washington, DC.;Dr. Opler is Adjunct Assistant Professor at NYU School of Medicine and Chief Research Officer at MedAvante-ProPhase Inc. in New York, New York.;Dr. Yavorsky is Chief Scientific Officer and Clinical Director at Cronos Clinical Consulting in Lambertville, New Jersey.

关键词: Positive and Negative Syndrome Scale;    PANSS;    rater;    rater training;    technology;    clinical trials;   

DOI  :  

学科分类：精神健康和精神病学

来源: Matrix Medical Communications, LLC

【 摘 要 】

Rater training and the maintenance of the consistency of ratings are critical to ensuring reliability of study measures and sensitivity to changes in the course of a clinical trial. The Positive and Negative Syndrome Scale (PANSS) has been widely used in clinical trials of schizophrenia and other disorders and is considered the “gold standard” for assessment of antipsychotic treatment efficacy. The various features associated with training and calibration of this scale are complex, reflecting the intricacy and heterogeneity of the disorders that the PANSS is used to evaluate. In this article, the authors review the methods for ensuring reliability of the PANSS as well as a proposed trajectory for its use in the future. An overview of the current principles, implementation, technologies, and strategies for the best use of the PANSS; tips for how to achieve consistency among raters; and optimal training practices of this instrument are presented.

【 授权许可】

Unknown