SALICYLIC ACID AS AN EFFICIENT CATALYST FOR THE DIASTEREOSELECTIVE SYNTHESIS OF DISPIROHYDROQUINOLINES VIA A ONE-POT DOMINO EIGHT-COMPONENT REACTION

Journal of The Chilean Chemical Society

Maghsoodlou, Malek Taher¹  Salahi, Sajjad²  Hazeri, Nourallah³ 

[1] University of Oviedo, Oviedo, Spain;University of Sistan and Baluchestan, Zahedan, Iran;Velayat University, Iranshahr, Iran

关键词: Aromatic aldehydes;    Aromatic amines;    Meldrum's acid;    Dispiro compounds.;   

DOI  :  10.4067/S0717-97072018000404159

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Salicylic acid was used as an efficient catalyst for the diastereoselective synthesis of dispirohydroquinoline-bis (Meldrim's acid) derivatives via a one-pot domino eight-component reaction of arylamines, aromatic aldehydes and Meldrum's acid in CH3CN at room temperature. The remarkable advantages offered by this method are inexpensive catalyst, good yields, simple and easy work-up procedure. The characterization of products was done by IR, mass, 1H NMR, 13C NMR spectroscopy, and elemental analyses. The stereoselectivity of compounds was confirmed with crystallography and NMR spectroscopy.

【 授权许可】

Unknown