期刊论文详细信息
Journal of Xenobiotics
Effects of chronic exposure to benzophenone and diclofenac on DNA methylation levels and reproductive success in a marine copepod
Kirsty F. Smith1  Louis A. Tremblay2  Maria P. Charry3  Olivier Champeau3  Anais Guyon4 
[1] European Institute for MarineStudies, University of Western Brittany,Plouzané;School of Biological Sciences, University of Auckland,Auckland;Cawthron Institute, Nelson;Cawthron Institute, Nelson, New Zealand
关键词: Gladioferens pectinatus;    Toxicity;    Multigenerational effects;    Reproduction;    Epigenetic;    Emerging contaminants;   
DOI  :  10.4081/xeno.2018.7674
学科分类:药理学
来源: Pagepress
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【 摘 要 】

The UV-filter benzophenone and the anti-inflammatory diclofenac are commonly detected in the environment. The aim of this study was to assess the multigenerational effects of chronic exposure to low concentrations of these chemicals on toxicity and DNA methylation levels in the copepod Gladioferens pectinatus. Acute toxicity tests were conducted to determine the sensitivity of G. pectinatus to the chemicals. All chemicals impacted breeding, hatching and egg viability. Diclofenac (1 mg.L-1) reduced the number of eggs per gravid female. Benzophenone (0.5 mg.L-1) decreased egg hatching success. Exposure to the reference toxicant copper (0.02 mg.L-1) led to unsuccessful hatching. Effects on DNA methylation was estimated by the percentage of 5- methylcytosine. The treatments resulted in strong differences in DNA methylation with increased methylation in the exposed animals. The two chemicals impacted both egg viability and the induction of differential DNA methylation, suggesting potential intra- and trans-generational evolutionary effects.

【 授权许可】

CC BY-NC   

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