Non-CpG Methylation Revised

Epigenomes

Fuso, Andrea¹ 

[1]Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena, 324-00161 Rome, Italy

关键词: DNA methylation;    non-CpG methylation;    DNMT3;    bisulfite assay;    neuroepigenetics;   

DOI  :  10.3390/epigenomes2040022

学科分类：分子生物学，细胞生物学和基因

来源: mdpi

【 摘 要 】

Textbook and scientific papers addressing DNA methylation usually still cite “DNA methylation occurs at CpG cytosines”. Methylation at cytosines outside the CpG nucleotide, the so-called “non-CpG methylation”, is usually considered a minor and not biologically relevant process. However, the technical improvements and additional studies in epigenetics have demonstrated that non-CpG methylation is present with frequency higher than previously thought and retains biological activity, potentially relevant to the understanding and the treatment of human diseases.

【 授权许可】

CC BY