Ototoxicity of boric acid powder in a rat animal model

Revista Brasileira de Otorrinolaringologia

Cesmeci, Enver¹  Dogru, Salim²  Kurt, Onuralp³  Caliskan, Halil⁴  Kuçukodaci, Zafer⁵  Salihoglu, Murat⁶ 

[1] Diyarbakir Military Hospital, Diyarbakir, Turkey;Efes Otolaryngology Branch Center, Izmir, Turkey;Erzincan Military Hospital, Erzincan, Turkey;Eskisehir Military Hospital, Eskisehir, Turkey;GATA Haydarpaa Training Hospital, Istanbul, Turkey;GATA Haydarpasa Training Hospital, Istanbul, Turkey

关键词: Boric acid;    Ear;    Otoacoustic emissions;    Rats.;   

DOI  :  10.1016/j.bjorl.2017.03.010

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Introduction: Boric acid, which has antiseptic and acidic properties, is used to treat external and middle ear infections. However, we have not found any literature about the effect of boric acid powder on middle ear mucosa and inner ear.Objective: The purpose of this study is to investigate possible ototoxic effects of boric acid powder on cochlear outer hair cell function and histological changes in middle ear mucosa in a rat animal model.Methods: Twenty healthy, mature Wistar albino rats were used in this study. The rats were divided into two groups, Group A and Group B, each of which consisted of 10 rats. Initially, the animals in each group underwent distortion product otoacoustic emissions testing of their right and left ears. After the first distortion product otoacoustic emissions test, a surgical microscope was used to make a small perforation in both ears of the rats in each group, and a second distortion product otoacoustic emissions test was used to measure both ears in all of the rats. Boric acid powder was applied to the right middle ear of the rats using tympanic membrane perforation, and the distortion product otoacoustic emissions were measured immediately after the boric acid powder application. The histological changes and distortion product otoacoustic emissions were evaluated three days later in Group A and 40 days later in Group B.Results: No significant differences were found at all of the distortion product otoacoustic emissions frequencies. In Group A, mild inflammation of the middle ear mucosa was found on the third day after boric acid powder application. In Group B, boric acid powder caused mild inflammatory changes on the 40th day, which declined over time. Those changes did not lead to significant fibrosis within the mucosa.Conclusion: In rats, boric acid powder causes mild inflammation in middle ear mucosa and it has no ototoxic effects on cochlear outer hair cell function in the inner ear of rats.

【 授权许可】

CC BY