The protective effects of crocin in the management of neurodegenerative diseases: a review

American Journal of Neurodegenerative Disease

Tahereh Farkhondeh¹  Saeed Samargh²  Hanieh Shaterzadeh Yazdi³  ian⁴ 

[1] Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran;Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran;Department of Neurosurgery, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;Research Center of Pardis Hospital, Mashhad, Iran

关键词: Crocins;    antioxidant;    anti-inflammation;    nervous system;   

DOI  :  

学科分类：精神健康和精神病学

来源: e-Century Publishing Corporation

【 摘 要 】

Flavonoids have been used in traditional medicine to promote human health. Crocin has been proposed to be effective in the management of the various diseases including the neurodegenerative diseases. Antiepileptic and anti-Alzheimer effects of crocin have also been indicated. The efficacy of crocis in the treatment of cerebral ischemia and traumatic brain injury was also confirmed by using animal models. Crocin treatment increased dopamine levels in the brain of experimental model of Parkinson’s disease. In addition, crocin modulates the opioid system to decrease the withdrawal syndrome. Thus, the present study highlighted the effects of crocin on the nervous system and the underling mechanisms. This review also indicated that crocins can be considered as an effective candidate in the management of nervous system diseases due to their antioxidant and anti-inflammation effects.

【 授权许可】

CC BY-NC