Protective effects of sodium tanshinone IIA sulfonate on cardiac function after myocardial infarction in mice

American Journal of Translational Research

Peng Wu¹ 

[1] Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, P. R. China

关键词: Sodium tanshinone IIA sulfonate;    myocardial infarction;    anti-inflammation;    anti-apoptosis;    angiogenesis;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Sodium tanshinone IIA sulfonate (STS), a water-soluble derivative of tanshinone IIA, has been used in traditional Chinese medicine for many years. Many experiments have demonstrated that STS has anti-inflammatory, anti-apoptosis and angiogenesis effects. However, it is unclear whether STS has the same beneficial effects on myocardial infarction in vivo. The aim of our experiments was to investigate whether STS could improve cardiac function and prevent myocardial remodeling after myocardial infarction (MI) in mice. The MI model was established by surgical ligation of the left anterior descending (LAD) coronary artery. Then the mice were randomly divided into STS and untreated groups. The results of treatment for 3 weeks showed that STS could increase the survival rate, reduce the release of some inflammatory cytokines, inhibit cell apoptosis and promote angiogenesis. The study presents a new potential treatment method for ischemic heart disease.

【 授权许可】

CC BY-NC