Assessment of mucosal changes associated with nasal splint in a rabbit model

Revista Brasileira de Otorrinolaringologia

Tan, Mehmet¹  Kalcioglu, M. Tayyar²  Sahin, Nurhan³ 

[1] Inonu University Medical Faculty, Malatya, Turkey;Istanbul Medeniyet University, Istanbul, Turkey;Zekai Tahir Burak Hospital, Ankara, Turke

关键词: Nasal mucosa;    Nasal septal perforation;    Nasal septum;    Tampons surgical.;   

DOI  :  10.1016/j.bjorl.2014.08.004

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

INTRODUCTION: There is no consensus on duration of the nasal splint after nasal septum surgeries. The pressure of nasal splint on the mucosa may cause tissue necrosis and nasal septum perforation.OBJECTIVES: To investigate the histopathological changes of the nasal mucosa caused by nasal splints in a rabbit model.METHODS: No splint was used in group A. Bilateral silicone nasal splints were placed for five, ten, and 15 days in groups B, C, and D, respectively. Biopsy of the nasal mucosa was performed after removal of splint. Histopathologic evaluations were performed. The severity and depth of the inflammation were scored.RESULTS: Group A had a normal histological appearance. Comparison of the results of groups B, C, and D with group A demonstrated statistically significant differences with regards to the severity of histopathological findings. There was no statistically significant difference between groups B and C. There were statistically significant differences between the groups B and D, and also between groups C and D.CONCLUSIONS: Longer duration of nasal splint had a higher risk for septal perforation. Therefore, removal of the splint as soon as possible may be helpful for preventing potential perforations.

【 授权许可】

CC BY