Combination therapy with liposomal amphotericin b (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate in a refractory visceral leishmaniasis case

Sociedade Brasileira de Medicina Tropical. Revista

Medeiros, Lana Lira Cantidio de¹  Lobo, Fernanda Paula Dantas²  Gomes, Maria Antonia Ferreira³ 

[1] Hospital Infantil Varela Santiago, Natal, Brasil;Universidade Federal do Rio Grande do Norte, Natal, Brazil;Universidade Potiguar, Natal, Brazil

关键词: Visceral leishmaniasis;    Refractory;    Treatment.;   

DOI  :  10.1590/0037-8682-0398-2017

学科分类：农业科学（综合）

来源: Sociedade Brasileira de Medicina Tropical

【 摘 要 】

Visceral leishmaniasis is a systemic disease that is potentially severe and endemic in Brazil. It clinically manifests as fever, weight loss, swelling, hepatosplenomegaly, paleness, and edema. In this study, we discuss a case of a 1-year-old child diagnosed with refractory visceral leishmaniasis after being treated with liposomal amphotericin B in two distinct occasions. Considering the persistent clinical features and weak response to conventional treatment, a combination therapy with liposomal amphotericin B (ambisome), n-methylglucamine antimoniate (glucantime), and pentamidine isethionate was initiated, and response to treatment was good.

【 授权许可】

CC BY