Protein Expressions of the Small GTPase Rho Proteins in Pterygial Tissue and Leukocytes of Patients with Pterygium

Proceedings

Düzen, Betül¹  Mete, Alper²  Temiz, Ebru³  Saracaloglu, Ahmet⁴  Kimyon, Sabit⁵  Demiryürek, Seniz⁶  Nacarkahya, Gülper⁷  Saygili, Oguzhan⁸ 

[1] Author to whom correspondence should be addressed.;Department of Medical Biochemistry, Faculty of Medicine, Harran University, 63290 Sanliurfa, Turkey;Department of Medical Biology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey;Department of Medical Pharmacology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey;Department of Ophthalmology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey;Department of Physiology, Faculty of Medicine, University of Gaziantep, 27310 Gaziantep, Turkey;Ophthalmology Clinic, Gaziantep Dr. Ersin Arslan Training and Research Hospital, 27010 Gaziantep, Turkey;Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018

关键词: expression;    leukocyte;    pterygium;    Rho proteins;   

DOI  :  10.3390/proceedings2251571

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Pterygium is a benign fibrovascular proliferation that develops from the conjunctiva and invades the cornea. The etiology of this disorder remains unclear. Current treatment of pterygium is surgical. The postoperative recurrence rate of pterygium is reported be high. To the best of our knowledge, these results are the first to demonstrate the contribution of proteins expressions of the small GTPase Rho proteins in patients with pterygium. Our data showed that leukocyte RhoA, RhoB, RhoD, and RhoE protein expressions were markedly elevated in primary pterygium. However, no significant modifications were noted in pterygial tissues.

【 授权许可】

CC BY