Late auditory event-related evoked potential (P300) in Down's syndrome patients

Revista Brasileira de Otorrinolaringologia

Caovilla, Heloisa Helena¹  César, Carla Patrícia Hernandez Alves Ribeiro² 

[1] Universidade Federal de São Paulo - Escola Paulista de Medicina;Universidade Metodista de São Paulo

关键词: down syndrome;    p300;    event-related potentials.;   

DOI  :  10.1590/S1808-86942010000200010

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease. AIM: to evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome. MATERIALS AND METHODS: Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. RESULTS The P300 latency (N1, P2, N2 and P3) was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group. CONCLUSION: In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced, suggesting integration impairment between the auditory association area and cortical and subcortical areas of the central nervous system.

【 授权许可】

CC BY