Bulletin of Materials Science | |
Synthesis, characterization and anticancer activity of selenium nanobiocomposite of L-asparaginase | |
G BASKAR^11  | |
[1] Department of Biotechnology, St. Joseph’s College of Engineering, Chennai 600 119, India^1 | |
关键词: Selenium nanobiocomposite; asparaginase; anticancer activity; colon cancer; human osteosarcoma; liver cancer.; | |
DOI : | |
学科分类:材料工程 | |
来源: Indian Academy of Sciences | |
【 摘 要 】
Selenium is a rare earth nonmetal and an essential micronutrient for animals, and a trace nutrient for humans. It is known to function as a cofactor for reduction of antioxidant enzymes, such as glutathione peroxidase. The selenium nanobiocomposite synthesized using a co-precipitation method with sizes 20â30 nm were confirmed using scanning electron microscopy and they showed maximum absorption between 300 and 400 nm in the ultra-violet spectrum. Fourier transform infrared and H-nuclear magnetic resonance analysis revealed the involvement of various functional groups in the binding of asparaginase to selenium nanoparticles to form the selenium nanobiocomposite. X-ray diffraction analysis confirmed the hexagonal structure of the selenium nanobiocomposite. Methylthiazolyl diphenyl-tetrazolium bromide assay on HT-29, MG-63 and HEPTOcells loaded with the selenium nanobiocomposite revealed a toxicity of 93.62, 94.24 and 87.68%, respectively, for a selenium nanobiocomposite concentration of 1000 $\mu$g ml$^{â1}$. The selenium nanobiocomposite ofL-asparaginase opens a new arena in cancer treatment.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO201910258810616ZK.pdf | 1159KB | download |