TRIFLUOROACETIC ACID CATALYZED ONE-POT FOUR-COMPONENT DOMINO REACTION FOR THE SYNTHESIS OF SUBSTITUTED DIHYDRO 2-OXYPYRROLES

Journal of The Chilean Chemical Society

Maghsoodlou, Malek Taher¹  Lashkari, Mojtaba² 

[1] University of Sistan and Baluchestan, Zahedan, Iran;Velayat University, Iranshahr, Iran

关键词: Trifluoroacetic acid;    N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates;    ambient temperature.;   

DOI  :  10.4067/s0717-97072018000103799

学科分类：化学（综合）

来源: Sociedad Chilena de Quimica

【 摘 要 】

Trifluoroacetic acid was applied as an efficient catalyst for the one-pot four-component synthesis of N-aryl/alkyl-3-aminodihydropyrrol-2-one-4-carboxylates via the domino reaction of amines, formaldehyde and dialkyl acetylenedicarboxylates at ambient temperature in methanol. This methodology includes number of advantages such as: short reaction time, clean work-up, use of inexpensive catalyst, high yields and clean work-up. The work-up of this reaction involves only a filtration and a simple washing step with MeOH, and there is no need for column chromatography.

【 授权许可】

Unknown